The Preoperative Predictors of Optimal Cytoreductive Surgery in Women With Advanced Epithelial Ovarian Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 主要终点
- feasibility of optimum cytoreduction
研究概览
简要总结
44 patients were enrolled in this study as they had malignant epithelial ovarian tumor.Pre-operative staging was assessed by CT scan based on FIGO classification and compared to the standard laparotomy surgical staging. Maximal surgical effort for Optimum cytoreduction was achieved and the risk factors for sub-optimal cytoreduction were studied
详细描述
Each patient was subjected to comprehensive medical history taking and careful clinical examination, laboratory investigations (CA-125) and imaging (abdomino-pelvic CT scan). Patients with suspected bowel involvement were subjected for colonoscopy.
Pre-operative Abdomino-pelvic CT scans:
Preoperative CT scans were performed with a high-speed scanner after the oral and intravenous administration of contrast medium. The hard copy images were reviewed by consultant radiologists for assessment of the findings suggestive of malignant adnexal mass which are bilateral lesions, thick septa, enhancing solid components, ascites, and peritoneal deposits .
Pre-operative staging of cancer ovary was assessed by CT scan based on FIGO classification:
- Stage II: tumor involving ovaries with pelvic extension +/- ascites.
- Stage III: tumor involving ovaries with peritoneal implant outside pelvis +/- ascites.
- Stage IV: tumor involving ovaries with parenchymal liver metastasis and/or pleural effusion.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 60 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •malignant epithelial ovarian tumor (EOC)
- •FIGO stage II, III, and IV.
排除标准
- •Patients with previous abdominal or pelvic major surgery, synchronous abdominal or pelvic pathology or medically unfit for surgery
结局指标
主要结局
feasibility of optimum cytoreduction
时间窗: 1 year after surgery
ability to remove all gross lesions from the tumor intraoperatively and leaving no ovarian lesion seen by naked eye of the expert surgeon
次要结局
未报告次要终点
研究者
Ahmed Maged
Assistant professor
Cairo University
