Sildenafil Citrate with melatonin and intrauterine growth restrictio

Not Applicable

Recruiting

Conditions: Intrauterine growth restriction.
Disorders of newborn related to slow fetal growth and fetal malnutrition

Registration Number: IRCT20160524028038N6

Lead Sponsor: Yasouj University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 88

Inclusion Criteria

Single-pregnancy pregnancy with IUGR
Pregnancy's age between 26 and 32 weeks
Mother's age between 18 to 45 years
No using alcohol and cigarettes
Normal anomaly scan
The absence of fetal with known or suspected anomalies
No gestational or chronic diagnosed diabetes
Not using other vasodilator drugs such as nitric oxide and calcium channel blockers

Exclusion Criteria

Lack of follow-up
Unwillingness to participate in the study
Complications such as premature rupture of membrane, vaginal bleeding, and intrauterine infection
Sildenafil sensitivity and tolerance to side effects (flushing, visual disturbances, severe drop in blood pressure and hearing impairment)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Weight percentile. Timepoint: At each visit pregnancy. Method of measurement: Ultrasound.;Abdominal circumference growth. Timepoint: At each visit pregnancy. Method of measurement: Ultrasound.;Fetal amniotic fluid index. Timepoint: At each visit pregnancy. Method of measurement: Ultrasound.;Pregnancy duration. Timepoint: End of pregnancy. Method of measurement: Questionnaire.;Neonate anthropometric measurements (height and weight). Timepoint: Delivery time. Method of measurement: Scales and meters.;Quality of life. Timepoint: End of intervention. Method of measurement: Questionnaire.;Sleep quality. Timepoint: End of intervention. Method of measurement: Questionnaire.

Secondary Outcome Measures