Clinical and Radiological Evaluation of Meniscal Healing After Percutaneous Intra-meniscal Injection of Platelet-rich Plasma (PRP)

Completed

• Conditions: Meniscus Lesion
• Interventions: Procedure: Intra-meniscal injection of platelet-rich plasma

• Registration Number: NCT03966638
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Meniscal lesions are a common pathology among athletes, and have an impact on the daily or sporting practice of patients. The consequences of surgical treatment are sometimes heavy.

Platelet-rich-plasma (PRP) has been shown to be effective in healing tendon and ligament lesions.

PRP has been injected under ultrasound in tendons or intra-articularly for several years.

This technique of meniscal percutaneous injection of PRP is now carried out for more than 2 years in our hospital, with satisfactory preliminary results, without any complication.

All patients in our study received an intra-meniscal injection of PRP, under echographic control. They were evaluated clinically and by Magnetic Resonance Imaging (MRI) before and at 6 months of the injection.

The aim of the study is to evaluate the efficacy of intra-meniscal injection of PRP on the symptomatology of the patients (pain, sport activities and daily life) at 6 months post-treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-11-01
• Study First Submitted: 2019-05-27
• Study First Submitted QC: 2019-05-28
• Study First Posted: 2019-05-29
• Primary Completion: 2020-04-30
• Study Completion: 2020-11-30
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-18
• Last Update Posted: 2022-03-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• isolated symptomatic meniscal lesion
• lesion confirmed by MRI
• grade II or III lesion touching the peripheral involvement of the middle segment,
• lesion treated by percutaneous intra meniscal PRP's injection
• IKDC score measured before injection and 6 months post-injection

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Exclusion Criteria

• other painful etiology of the knee
• emergency surgical management (luxation, bucket handle) or not (indication validated by the surgeon, meniscectomy or meniscal suture)
• impossibility to perform the procedure (non visible lesion, morphology of the patient, cutaneous infection, coagulation treatment in progress)

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients receiving platelet rich plasma	Intra-meniscal injection of platelet-rich plasma	The group is composed of patients receiving an intra-meniscal injection of platelet-rich plasma, under echographic control, for isolated meniscal lesion.

Primary Outcome Measures

Name	Time	Method
Variation of International Knee Documentation Committee (IKDC) score	Between 0 and 6 months post injection	The variation of IKDC score between before injection and 6 months post-injection will be calculated. The IKDC score ranges from 0 to 100 and is interpreted as a measure of function with higher scores representing higher levels of function.

Trial Locations

Locations (1)

Department of Radiology, Croix-Rousse Hospital, Hospices Civils de Lyon; 🇫🇷 Lyon, France