Electrolytes in Chronic Kidney Disease Patients With Acute Coronary Syndrome

• Conditions: Acute Coronary Syndrome
• Interventions: Diagnostic Test: Serum Calcium

• Registration Number: NCT05134220
• Lead Sponsor: Sohag University

Brief Summary

Study of serum calcium and phosphorus level in chronic kidney disease patients and its relation to occurrence of acute coronary syndrome in them.

Detailed Description

Prospective study to :

1. find the relation between electrolytes disturbance and renal diseases

2. the effect of electrolyte abnormalities on atherosclerosis

3. prevalence of acute coronary syndrome in patients with chronic kidney disease

Study Timeline

• Status Verified: 2021-11
• Study First Submitted: 2021-11-06
• Study First Submitted QC: 2021-11-22
• Last Update Submitted: 2021-11-22
• Study First Posted: 2021-11-24
• Last Update Posted: 2021-11-24
• Study Start: 2021-11-30
• Primary Completion: 2022-05-30
• Study Completion: 2022-05-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• 1-The CKD patients with or without dialysis who admitted to coronary care unit with chest pain consistent with ACS with any of following features :

  a- Electrocardiogram (ECG) changes:

• ST elevation.

• ST depression.

• T wave inversion.

• recent left bundle branch block.

  b- Troponin T elevation.

  2-The CKD patient with or without dialysis with no previous history of ACS.

Exclusion Criteria

1. Patients who were diagnosed with primary hyperparathyroidism.

2. Acute Kidney injury (AKI) which is defined as any of the following:(KDIGO2012)

   • Increase in S.Cr by ≥ 0.3 mg/dl (≥ 26.5 μmol/l) within 48hours; or
   • Increase in S.Cr to ≥ 1.5 times baseline, which is known or presumed to have occurred within the prior 7 days;or
   • Urine volume <0.5 ml/kg/h for 6 hours

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Chronic Kidney Disease (CKD) patients without acute coronary syndrome	Serum Calcium	The CKD patient with or without dialysis with no previous history of ACS.
Chronic Kidney Disease (CKD) patients with acute coronary syndrome	Serum Calcium	The CKD patients with or without dialysis who admitted to coronary care unit with chest pain consistent with ACS with any of following features : 1. Electrocardiogram (ECG) changes: * ST elevation. * ST depression. * T wave inversion. * recent left bundle branch block. 2. Troponin elevation.

Primary Outcome Measures

Name	Time	Method
Chronic kidney disease hospitalization	from the day of admission to the day of discharge through study completion, an average of 28 weeks, in sohag university hospital	The CKD patient with and without acute coronary syndrome and estimated hazard ratios (HR) by use of multivariable Cox regression models.

Trial Locations

Locations (1)

Sohag university; 🇪🇬 Sohag, Egypt