Risk Factors of Perforated HSCR in Neonates
Completed
- Conditions
- Bowel; Perforation, Fetus or NewbornHirschsprung Disease
- Interventions
- Procedure: Emergency surgical enterostomy
- Registration Number
- NCT05044741
- Lead Sponsor
- Tongji Hospital
- Brief Summary
Hirschsprung's disease (HSCR) is a common digestive malformation with radiographic evidence of distal bowel obstruction and clinical signs of abdominal distension, vomiting, constipation, and failure to pass meconium. Bowel perforation (perforated HSCR) is a very serious complication of HSCR, but if this occurs it is most often in the neonatal period. The current study collected information on all cases diagnosed with perforated HSCR from multi-centers in China over 10 years, the aim was to evaluate the clinical features of perforated HSCR, and investigate possible risk factors for perforated HSCR in neonates.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 600
Inclusion Criteria
- Neonates (≤1 month age)
- Diagnosed with HSCR
- Suffered with bowel perforation
Exclusion Criteria
- Patients complicated with suspected necrotizing enterocolitis (NEC), imperforate anus (IA), intestinal atresia, and meconium plug syndrome
- Neonates who transferred from outside participating hospitals.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Perforated group Emergency surgical enterostomy -
- Primary Outcome Measures
Name Time Method Rate of bowel perforation in neonatal Hirschsprung disease (perforated HSCR) 14 years Cases with bowel perforation in neonatal Hirschsprung disease/ total neonatal Hirschsprung disease
- Secondary Outcome Measures
Name Time Method