Capillary rarefaction in chronic kidney disease (CKD) (Cap-CKD): A survey on microvasculature and renal function in patients undergoing a nephrectomy
Withdrawn
- Conditions
- kidney failurekidney disease1003843010057166
- Registration Number
- NL-OMON46422
- Lead Sponsor
- Pathologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Withdrawn
- Sex
- Not specified
- Target Recruitment
- 281
Inclusion Criteria
Patients who undergo a nephrectomy for a suspected renal cell carcinoma and who are 18 years or older and are able to read and write.
Exclusion Criteria
none
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Primary Objective:<br /><br>The primary objective of the study is to assess the relationship between renal<br /><br>PTC density and renal function before and two years after surgery.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Secondary Objectives:<br /><br>The secondary objectives of the study are to assess<br /><br>a) the relationship between renal PTC density and systemic capillary density<br /><br>and microvascular function in patients with and without CKD at nephrectomy and<br /><br>after two years.<br /><br>b) the relationship between renal PTC density and histological and molecular<br /><br>damage (e.g. IF/TA, inflammation, angiogenic profiling, MSI) in renal tissue in<br /><br>patients with and without CKD at nephrectomy and after two years.<br /><br>c) the relationship between renal PTC density and renal function in relation to<br /><br>known cardiovascular risk factors such as demographic variables (age, gender),<br /><br>clinical variables (renal function, hypertension. glucose intolerance, mineral<br /><br>metabolism, BMI), and medical history (smoking history, medication use, birth<br /><br>weight).<br /><br></p><br>