Effect of combined electrical muscle stimulation and resistance exercises on duration of mechanical ventilation in critically ill patients: a randomized controlled trial

Not Applicable

Completed

• Conditions: mechanical ventilation; muscle dysfunction; critical illness; Musculoskeletal - Other muscular and skeletal disorders; Physical Medicine / Rehabilitation - Physiotherapy

• Registration Number: ACTRN12614001059651
• Lead Sponsor: niversity of Brasilia Brazil

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-10-03
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

All patients consecutively admitted to the multidisciplinary ICU of San Jose Hospital during the study period were considered for inclusion in the study. All patients who had been on mechanical ventilation for less than 72 hours, and were expected to continue for at least 24 hours, were included.

Exclusion Criteria

preexisting neuromuscular disease (e.g. Myasthenia Gravis, Guillain-Barre disease), cardiopulmonary arrest, end-stage malignancy, raised intracranial pressure, or technical obstacles that did not allow the implementation of EMS such as bone fractures or skin lesions

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
duration of mechanical ventilation (discontinuation of mechanical ventilation support with no need of return for mechanical ventilation until intensive care unit discharge)[at discharge from intensive care unit]

Secondary Outcome Measures

Name	Time	Method
length of stay in intensive care unit[the moment when the patient was discharged from intensive care unit];Biomarker analysis[Participants who consent to participation will also be<br>approached for consent to biomarker assessment involving<br>blood samples. Venous blood (15 ml) will be collected at each time point and processed to obtain plasma and serum for <br>subsequent analyses. Stored plasma and serum will be<br>analysed using ELISA methods for IGF-1, IL-1 beta, IL-6,<br>IL-10, IL-18 and TNF-alpha. Biomarker assessment will be performed at baseline, and at ICU discharge (where possible<br>the ‘ICU discharge’ measure will occur 24 h post final<br>intervention exercise session).]