Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.

Not Applicable

• Conditions: Ischemic Optic Neuropathy; Traumatic Optic Neuropathy; Hereditary Optic Neuropathies; Toxic Optic Neuropathy; Optic Neuritis; Compressive Optic Neuropathy

• Registration Number: NCT05353413
• Lead Sponsor: Medical University of Bialystok

Brief Summary

The aim of the project is to create a new, non-invasive and safe protocol for the early diagnosis of various types of optic neuropathies with the use of diffusion magnetic resonance imaging

Detailed Description

In this study, it is planned to find twenty volunteers for each of the neuropathies and twenty healthy volunteers. Each volunteer will undergo clinical tests such as visual acuity, color vision, intraocular pressure measurement, assessment of the anterior chamber and fundus using a slit lamp and Volk lens, macular optical coherence tomography examination and examination of the optic nerve disc (OCT), neurological field vision and visual evoked potential (VEP) testing. Each of the volunteers will undergo magnetic resonance imaging. During active scanning, patients will be asked for not blinking or moving their heads by staring at the red dot on the outside of the camera reflected in the coil mirror. The obtained diffusion tensor data will be used for further analysis.

Study Timeline

• Study Start: 2020-01-01
• Status Verified: 2022-03
• Study First Submitted: 2022-03-16
• Study First Submitted QC: 2022-04-28
• Last Update Submitted: 2022-04-28
• Study First Posted: 2022-04-29
• Last Update Posted: 2022-04-29
• Primary Completion: 2024-01-01
• Study Completion: 2024-01-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Optic neuropathy.

Exclusion Criteria

common contraindications to MRI (presence of pacemaker, non-MRI-safety or claustrophobia)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
sigma parameter	one month	sigma parameter in our algorithm provides a quantitative measure of nerve atrophy

Trial Locations

Locations (1)

Lisowski; 🇵🇱 Wasilkow, Poland