NL-OMON42442招募中不适用
The role of the immune system in Q Fever Fatigue Syndrome - QFS - Immunopathology
Stichting Q-support (verlenen subsidie)0 个研究点目标入组 80 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 80
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Q Fever Fatigue Syndrome (QFS):
- •Diagnosis of QFS according to national LCI-guideline Q fever fatigue syndrome (QFS)
- •Score >=40 on the subschale fatigue of the Checklist Individual Strength (CIS)
- •Severe functional impairment on Sickness Impact Profile-8 (SIP-8), defined as a SIP total score >=700
- •Age >=18;Chronic Fatigue Syndrome (CFS):
- •Diagnosed with CFS according to CDC-criteria (www.cdc.gov/cfs)
- •Score >=40 on the subschale fatigue of the CIS
- •Severe functional impairment on Sickness Impact Profile-8 (SIP-8), defined as a SIP total score >=700
- •Age >=18;Cleared acute Q fever without residual symptoms:
- •Cleared acute Q fever (without residual symptoms)
- •Age >=18;Healthy serologic negative volunteers:
- •Negative Q fever serology as tested by immunofluorescence assay (IFA)
- •Age >=18
排除标准
- •Q Fever Fatigue Syndrome (QFS):
- •Use of immunosuppressant drugs during an acute Q fever infection or in the past 3 months
- •Use of antibiotics that are potentially active against C. Burnetii for at least 4 weeks, after the diagnosis acute Q fever was made;Chronic Fatigue Syndrome (CFS):
- •Use of immunosuppressant drugs in the past 3 months
- •History of Q fever
- •Chronic Q fever patients, according to the Dutch consensus *Chronic Q fever*
- •Vaccinated for Q fever
- •Pregnancy;Cleared acute Q fever without residual symptoms:
- •Use of immunosuppressant drugs during an acute Q fever infection or in the past 3 months
- •Chronic Q fever patients, according to the national consensus *Chronic Q fever* [RIVM, Q-koortsvermoeidheidssyndroom]
- •Vaccinated for Q fever
- •QFS or CFS
- •Evident somatic or psychiatric morbidity
- •Pregnancy ;Healthy serologic negative volunteers:
- •Use of immunosuppressant drugs in the past 3 months
- •History of Q fever
- •Chronic Q fever patients, according to the national consensus *Chronische Q-koorts*
- •Vaccinated for Q fever
- •QFS or CFS
- •Evident somatic or psychiatric morbidity
研究者
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