Three-dimensional Choroidal Vascularity Index in Common Fundus Diseases

• Conditions: Choroid
• Interventions: Other: no intervention

• Registration Number: NCT04790084
• Lead Sponsor: Renmin Hospital of Wuhan University

Brief Summary

Explore the changes of choroidal blood perfusion in common fundus diseases by three-dimensional choroidal vascularity index, an optical coherence tomography (OCT) parameter.

Detailed Description

Compared with the choroidal vascularity index on a single OCT image, the three-dimensional choroidal vascularity index can evaluate the choroidal changes of chorioretinal diseases as a whole. In this study, the choroidal changes of patients with common fundus diseases were systematically evaluated by collecting OCT and optical coherence tomography angiography (OCTA) images of patients with common fundus diseases, especially in healthy people, myopic people and patients with central serous chorioretinopathy.

Study Timeline

• Status Verified: 2021-03
• Study First Submitted: 2021-03-03
• Study Start: 2021-03-04
• Study First Submitted QC: 2021-03-06
• Last Update Submitted: 2021-03-06
• Study First Posted: 2021-03-10
• Last Update Posted: 2021-03-10
• Primary Completion: 2024-03-10
• Study Completion: 2024-03-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

1. without systemic diseases such as diabetes and hypertension 2) best corrected visual acuity BCVA ≥ 1.0 3) aged 18 years or older (2) Exclusion criteria: 1) equivalent spherical refraction between -3 diopters and + 1.0 diopters 2) any visible lesions in the retina, optic nerve, or choroid 3) history of refractive or intraocular surgery

2. Myopia group (1) Inclusion Criteria: 1) equivalent spherical refraction greater than -0.25 diopters 2) without systemic diseases such as diabetes and hypertension 3) Best corrected visual acuity (BCVA) ≥ 1.0 4) aged 10 years or older (2) Exclusion criteria: 1) history of refractive or intraocular surgery 2) history of laser therapy 3) other systemic diseases that may affect the choroid
3. Central serous chorioretinopathy (CSC) group (1) Inclusion Criteria: 1) a diagnosis of CSC (2) Exclusion criteria: 1) high myopia or hyperopia (greater than 26 or +3 diopters of refractive error) 3) other systemic diseases that may affect the choroid 4) any other associated retinal pathology 5) history of refractive or intraocular surgery

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Healthy-Myopia-CSC	no intervention	Cross-sectional study, no intervention, only collecting OCT,OCTA images and other eye parameters of patients.

Primary Outcome Measures

Name	Time	Method
Three-dimensional choroidal vascularity index	baseline, pre-intervention	Three-dimensional choroidal vascularity index of healthy people and patients with common fundus diseases, based on optical coherence tomography.

Secondary Outcome Measures

Name	Time	Method
Choriocapillaris flow deficits%	baseline, pre-intervention	Choriocapillaris flow deficits% of healthy people and patients with common fundus diseases, based on optical coherence tomography angiography.

Trial Locations

Locations (1)

Renmin Hospital of Wuhan University; 🇨🇳 Wuhan, Hubei, China