Comparative evaluation of dexamethasone, vitamin-c and platelet growth factors in postoperative sequelae of impacted third molar: Randomised Clinical Trial
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- 1.Pain assessment (VAS Scale)
研究概览
简要总结
This study evaluates postoperative sequelae following surgical removal of impacted mandibular third molars using Gelfoam impregnated with concentrated growth factors, vitamin C, and dexamethasone placed in the extraction socket. Concentrated growth factors promote wound healing and tissue regeneration, vitamin C enhances collagen synthesis and provides antioxidant support, while dexamethasone helps in controlling postoperative inflammation. Postoperative pain, facial swelling, and trismus were assessed at predetermined intervals to evaluate clinical outcomes. The study aims to determine the effectiveness of this combined local application in reducing postoperative complications and improving patient recovery and comfort following impacted third molar surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients categorized under ASA-I and ASA-II health status Mesioangular, Position B, Level 2 mandibular third molar impaction.
排除标准
- •Pregnant & Lactating mother Patient having active infection in or around surgical site Patients on long-term steroid therapy Patients not willing to participate in the study.
结局指标
主要结局
1.Pain assessment (VAS Scale)
时间窗: Day 3, 1 week, and 2 weeks postoperatively
2.Swelling evaluation (Facial measurements)
时间窗: Day 3, 1 week, and 2 weeks postoperatively
3.Mouth opening (Interincisal width)
时间窗: Day 3, 1 week, and 2 weeks postoperatively
次要结局
- Analgesic consumption(Day 3, 1 week, and 2 weeks postoperatively)
研究者
DR AMBHUJA AGRAWAL
Saraswati Dental College and Hospital