Effect of Different Does of Dexmedetomidine on Oxygenation and Lung Mechanics
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 176
- 试验地点
- 1
- 主要终点
- Oxygenation by the end study
研究概览
简要总结
Dexmedetomidine is a selective α -2 agonist widely used in anesthesia for its sympatholytic, sedative and analgesic effects . Favorable respiratory effects in animals , and in selected human patient groups have been reported when using this agent .we investigated the effects of different doses of dexmedetomidine infusion on oxygenation
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Morbidly obese patients with restrictive lung disease ASA I AND II laparoscopic sleeve gastrectomy
排除标准
- •history of heart failure history of cardiac arrhythmias severe liver or kidney impairment. Patients with forced expiratory volume in 1 sec (FEV1)/ FVC < 70%
研究组 & 干预措施
group A
Dexmedetomidine (Precedex) loadings of 1 μg/kg than continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
干预措施: GROUP Dexmedetomidine (Drug)
group B
Dexmedetomidine (Precedex) loadings of 0.5 μg/kg then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
干预措施: GROUP B (Drug)
group C
Dexmedetomidine (Precedex) loadings of 0.25 μg/kg(group C) then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
干预措施: GROUP C (Drug)
结局指标
主要结局
Oxygenation by the end study
时间窗: UP TO 6 HOURE
PaO2/Fraction of inspired oxygen
次要结局
- Physiological dead space(UP TO 6HOURE)
- Intraoperative dynamic lung compliance(up to 6 hours)
- Intraoperative static lung compliance(UP TO 6 HOURE)
研究者
Amr Samir Wahdan
Assistant Professor
Cairo University