Effect of Dexmedetomidine on Oxygenation and Lung Mechanics

Not Applicable

Not yet recruiting

• Conditions: Drug Use; Dexmedetomidine
• Interventions: Drug: GROUP B; Drug: GROUP Dexmedetomidine; Drug: GROUP C

• Registration Number: NCT06355960
• Lead Sponsor: Cairo University

Brief Summary

Dexmedetomidine is a selective α -2 agonist widely used in anesthesia for its sympatholytic, sedative and analgesic effects . Favorable respiratory effects in animals , and in selected human patient groups have been reported when using this agent .we investigated the effects of different doses of dexmedetomidine infusion on oxygenation

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-03-28
• Status Verified: 2024-04
• Study Start: 2024-04-01
• Study First Submitted QC: 2024-04-02
• Last Update Submitted: 2024-04-02
• Study First Posted: 2024-04-10
• Last Update Posted: 2024-04-10
• Primary Completion: 2025-04-01
• Study Completion: 2025-05-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 176

Inclusion Criteria

Morbidly obese patients with restrictive lung disease ASA I AND II laparoscopic sleeve gastrectomy

Read More

Exclusion Criteria

history of heart failure history of cardiac arrhythmias severe liver or kidney impairment. Patients with forced expiratory volume in 1 sec (FEV1)/ FVC < 70%

Read More

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
group B	GROUP B	Dexmedetomidine (Precedex) loadings of 0.5 μg/kg then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
group A	GROUP Dexmedetomidine	Dexmedetomidine (Precedex) loadings of 1 μg/kg than continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .
group C	GROUP C	Dexmedetomidine (Precedex) loadings of 0.25 μg/kg(group C) then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation .

Primary Outcome Measures

Name	Time	Method
Oxygenation by the end study	UP TO 6 HOURE	PaO2/Fraction of inspired oxygen

Secondary Outcome Measures

Name	Time	Method
Physiological dead space	UP TO 6HOURE	1.14 (PaCO2-EtCO2)/ PaCO2-0.005
Intraoperative dynamic lung compliance	up to 6 hours	tidal volume/ (peak airway pressure -PEEP)
Intraoperative static lung compliance	UP TO 6 HOURE	Tidal volume/ (plateau pressure - PEEP)

Trial Locations

Locations (1)

Cairo university; 🇪🇬 Cairo, Egypt