A RANDOMIZED CLINICAL STUDY ON THE EFFECT OF TWO ANAESTHETIC TECHNIQUES ON VARIOUS LABORATORY BIOMARKERS AFTER SPINE SURGERY
试验速览
- 阶段
- Phase 3 4
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- 1.To compare the effect of two anaesthetic techniques (General Anaesthesia alone vs General Anaesthesia combined with Ultrasound-guided Erector Spinae Plane Block) on various laboratory biomarkers (testosterone,cortisol, CRP, glucose) in patients undergoing spine surgeries.
研究概览
简要总结
Spine surgeries are long and stressful. the patients suffer post operative stress and pain severely. This study is directed towards comparing stress markers and post operative pain and hemodynamic parameters in patients undergoing spine surgery under general anaesthesia with erector spinae block and without the block. Previous studies have shown beneficial effects with erector spinae block.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- None
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Ammerican Society of Anaesthesiologists ASA physical status I–III All patients admitted in CSSH scheduled to undergo spine surgeries.
排除标准
- •1.Type I or type II diabetes.
- •2.Oral contraceptives or Oestrogen therapy.
- •3.Body mass index more than 40 kg/m
- •4.Chronic analgesic therapy.
- •5.History of opioid dependence.
- •6.Those who receiving anticoagulation or experiencing any bleeding disorder.
- •7.Patients who required repeated surgical interventions.
- •8.Patient using chronic analgesic medication.
- •9.Psychiatric disorder.
- •10.Severe Hepatic , renal and neurological disease.
- •11.Emergency operation.
结局指标
主要结局
1.To compare the effect of two anaesthetic techniques (General Anaesthesia alone vs General Anaesthesia combined with Ultrasound-guided Erector Spinae Plane Block) on various laboratory biomarkers (testosterone,cortisol, CRP, glucose) in patients undergoing spine surgeries.
时间窗: 1.Glucose preoperative and postoperative after 6 hours | 2.Testosterone, Cortisol, CRP preoperative and postoperative after 3 days
次要结局
- 1.To compare the haemodynamic parameters: Mean arterial pressure and Heart rate.(2.To assess the association between the anaesthetic technique in post operative pain score(VAS).)
研究者
CHINTA RAMYAKRISHNA
Subharti Medical College