Corelation Between Circulating Nuclearsome and SIRS Happened After Congential Cardiac Surgery
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 100
- Locations
- 1
- Primary Endpoint
- the perioperation change of histone level
Study Overview
Brief Summary
In this study，the investigators want to determine the corelation between circulating nuclearsome and the development of SIRS occured after congenital cardiac surgery, including the serverity of organ damage and inflamation.
Detailed Description
Blood was collected from study participants at 6 time points; 1) post-anesthesia induction, 2) post-op hour 0, 3) post-op hour 4, 4) post-op hour 24, 5) post-op hour 48, and 6) post-op hour 72. At each of the 6 time points blood was analyzed for levels of the following:histone,blood routine test , c-reaction protein, procalcitonin, N-terminal pro-brain natriuretic,the hepatorenal function，cardiac function and pulmonary function
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Retrospective
Eligibility Criteria
- Ages
- 1 Month to 3 Years (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •children with congenial heart disease
Exclusion Criteria
- •Less than 2.5kg
- •Prematurity less than 37 weeks estimated gestational age
- •Renal failure as described by the pediatric RIFLE criteria
Outcomes
Primary Outcomes
the perioperation change of histone level
Time Frame: preoperation to 72 hours after congential cardiac surgery
Secondary Outcomes
- the perioperation change of blood routine test(preoperation to 72 hours after congential cardiac surgery)
- the perioperation change of cardiac function(preoperation to 72 hours after congential cardiac surgery)
- the perioperation change of c-reaction protein level(preoperation to 72 hours after congential cardiac surgery)