Early cessation of sedation and TTM in patients with a favourable EEG after cardiac arrest: a feasibility and safety study

• Conditions: cardiac arrest; Postanoxic encephalopathy; 10014623

• Registration Number: NL-OMON56493
• Lead Sponsor: Medisch Spectrum Twente

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

- Patients after cardiac arrest admitted to the ICU for treatment with
sedation, TTM and mechanical ventilation.
- Age 18 years or older.
- Continuous EEG measurement started within 12 hours after cardiac arrest.
- Favourable EEG pattern within 12 hours after arrest, defined as a continuous
background pattern (NVN, 2019; Ruijter et al., 2019).
- Possibility to stop sedative treatment within three hours after
identification of a favourable EEG pattern.
- Written informed consent (deferred).

Exclusion Criteria

- A known history of another medical condition with limited life expectancy (<6
months).
- Any progressive brain illness, such as a brain tumour or neurodegenerative
disease.
- Pre-admission Glasgow Outcome Scale Extended score of 4 or lower.
- Reason other than neurological condition to continue sedation and/or
ventilation.
- Follow-up impossible due to logistic reasons.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcome measure for the feasibility study will be the mechanical<br /><br>ventilation time in hours.</p><br>