A prospective cohort study of nutritional status and uremic toxin removal during long-term periods of super high-flux hemodialysis in chronic hemodialysis patients and the effect of RNA sequencing on peripheral blood mononuclear cells

Phase 3

• Conditions: End stage kidney disease required hemodialysis (Prevalence case); super high-flux hemodialysis; nutrition assessment; RNA sequencing; middle molecule uremic toxin; protein bound uremic toxin

• Registration Number: TCTR20210510002
• Lead Sponsor: Faculty of medicine, Naresuan University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-10
• Study Completion: 2022-06-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Age > 18 years old
Prevalence case of hemodialysis at least 3 months
Hemodialysis 3 times/week with adequate Kt/V > 1.2
Serum albumin > 3 mg/dL
Auria
Vascular access are eligible for blood flow rate > 400 ml/min
Adequate dry weight with BCM +/- OH 2 kg
Hemodynamic stability more than 2 weeks
Inform consent

Exclusion Criteria

Chronic infection or active cardiovascular diseases 3 month prior to recruitment
Metastasis malignancy
Advance cirrhosis
Pregnancy
Hemodynamic instability
Contraindication to anticoagulant
Refuse to informed consent
Serum albumin levels < 3 mg/d

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
utrition assessment Before and after intervention every 3 months Serum albumin levels

Secondary Outcome Measures

Name	Time	Method
utrition assessment Before and after intervention every 3 months Body composition analysis,Efficacy Before and after intervention every 3 months spKt/V,Efficacy Before and after intervention every 3 months Beta 2 microglobulin,Efficay Before and after intervention every 3 months Kappa light chain,Efficacy Before and after intervention every 3 months Lambda light chain,Albumin loss in dialysate Before and after intervention every 6 months Albumin measure,Efficacy Before and after intervention RNA sequencing in PBMCs