Calcified Cerebral Embolism: a Descriptive Study in a Large Single Center Cohort

Recruiting

• Conditions: Calcified Cerebral Embolism
• Interventions: Other: None, purely observational study

• Registration Number: NCT06309069
• Lead Sponsor: Centre Hospitalier Universitaire de Nīmes

Brief Summary

Calcified cerebral embolism (CCE) is a relatively rare but underdiagnosed cause of infarction. CCE diagnosis is made by CT. Radiological characteristics of CCE have been reported in small case series. The aim of this study was to describe clinical and radiological characteristics of CCE in a large number of patients, and to compare patients with different radiological CCE characteristics.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-02-26
• Study First Submitted QC: 2024-03-06
• Study First Posted: 2024-03-13
• Study Start: 2024-04-16
• Status Verified: 2024-05
• Last Update Submitted: 2024-05-13
• Last Update Posted: 2024-05-16
• Primary Completion: 2025-04
• Study Completion: 2025-04

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 79

Inclusion Criteria

• Patients with CEE treated with intravenous thrombolysis (IVT) between 2015 and 2020 managed at the CHU de Nîmes or Patients with TIA/stroke with ECC identified on CT between 12/2019 and 04/2023 managed at CHU de Nîmes

Exclusion Criteria

• Patient's refusal to use his/her data

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with CCE	None, purely observational study	CCE patients identified between 2015 and 2023

Primary Outcome Measures

Name	Time	Method
calcified aortic valves	baseline	looking for calcified aortic valves (presence/absence)
Calcified aortic brachiocephalic	baseline	looking for calcified aortic brachiocephalic (presence or absence)
calcified aortic arch	baseline	looking for calcified aortic arch (presence/absence)
calcified carotid	baseline	looking for calcified carotid (presence/absence)
history of surgical/endovascular cardiovascular intervention	baseline	surgical/endovascular cardiovascular intervention (y/n)
NIHSS	baseline	NIHSS score (Score between 1 and 4: minor stroke, Score between 5 and 15: moderate, stroke, Score between 15 and 20: severe stroke) Score \> 20: severe stroke
CCE diameter	baseline	CCE diameter measurement (mm)
calcified mitral valves	baseline	looking for calcified mitral valves (presence/absence)
cardiovascular risk	baseline	Study of cardiovascular risk factors (presence or absence)
history of stroke	baseline	Presence of a history of stroke (y/n)
Population	baseline	demographic characteristics sexe (M/F)
atherosclerotic plaques	baseline	looking for atherosclerotic plaques (presence/absence)
density	baseline	CCE density (uh)
involved cerebral artery	baseline	description of involved cerebral artery

Trial Locations

Locations (1)

CHU de Nîmes; 🇫🇷 Nîmes, France