Assessment of Bronchial Obstruction in Adolescents With HIV

Not Applicable

Completed

• Conditions: HIV
• Interventions: Diagnostic Test: pulmonary function tests

• Registration Number: NCT05869084
• Lead Sponsor: Assistance Publique - Hôpitaux de Paris

Brief Summary

In children, data from the literature find a higher prevalence of asthma in the population treated for HIV. Bronchial hyperreactivity, indicative of chronic inflammation and bronchial obstruction, is also present.

Screening for early peripheral obstruction could therefore make it possible to initiate appropriate anti-inflammatory treatment, if necessary, and early preventive management.

Detailed Description

In adults chronically infected with HIV, there is an increased prevalence impaired respiratory function, with a greater occurrence of COPD than in the uninfected population. In children, data from the literature find a prevalence of greater atopy in the HIV-infected pediatric population. Furthermore, a bronchial hyperreactivity or even peripheral bronchial obstruction, indicative of a local chronic inflammation has been found in young adolescents treated since the birth for HIV infection in utero. Screening for early peripheral obstruction in HIV-infected adolescents could therefore make it possible to initiate, if necessary, a anti-inflammatory treatment, and early management to prevent the occurrence of impaired respiratory function in adulthood For this this single-center prospective study chose to perform respiratory function explorations with forced oscillometry with the Endpoint main factor of the peripheral obstruction the R5HZ parameter expressed in % predicted. Patients from 11 to 25 years to whom it was proposed added to that to answer a questionnaire of respiratory quality of life

Study Timeline

• Study Start: 2022-03-01
• Primary Completion: 2022-06-01
• Study Completion: 2022-07-01
• Status Verified: 2023-05
• Study First Submitted: 2023-05-11
• Study First Submitted QC: 2023-05-11
• Last Update Submitted: 2023-05-11
• Study First Posted: 2023-05-22
• Last Update Posted: 2023-05-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Children over 11 and Under 25-year-old infected with HIV and on antiretrovirals and followed up at Robert Debré hospital for this pathology
• Consent of the holders of parental authority and Patients informed and not objecting to participate in research Exclusion Criteria : •
• Age ≤ 11 years old
• Not treated for HIV
• Patients under guardianship / curatorship

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
pulmonary function tests	pulmonary function tests	-

Primary Outcome Measures

Name	Time	Method
Resistance measured by forced oscillometry (5hZ)	24 hours	Resistance measured by forced oscillometry (5hZ)

Trial Locations

Locations (1)

Robert Debre Hospital; 🇫🇷 Paris, France