Effect of Immersive Virtual Reality Exergames in Patients With Parkinson's Disease

Not Applicable

Completed

• Conditions: Parkinson Disease
• Interventions: Device: Virtual reality exergames

• Registration Number: NCT04787549
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The study aimed to investigate the effect of applying cognitively challenging exergames using fully immersive virtual reality in patients with Parkinson's disease.

Detailed Description

It has been reported that dual-task training involving both cognitive and physical functions helps improve walking speed during dual-task performance without increasing the fall risk in patients with Parkinson's disease (PD). Compared with conventional physical therapy, there are studies that dual-task training significantly improved walking speed and stride in PD patients. In addition, a systematic review study has been reported that it helps to improve balance and cognitive function when dual-task training is performed for patients with neurological diseases including Parkinson's disease.

Virtual reality is expected to promote functional recovery in patients with neurological disorders in terms of providing an enriched environment, goal-directed tasks and repetition, and inducing interest and motivation. Therefore, the study aimed to investigate the effect of applying cognitively challenging exergames using fully immersive virtual reality in patients with PD.

Study Timeline

• Study First Submitted: 2021-03-01
• Study First Submitted QC: 2021-03-05
• Study First Posted: 2021-03-08
• Study Start: 2021-07-20
• Status Verified: 2022-01
• Primary Completion: 2022-01-27
• Study Completion: 2022-01-27
• Last Update Submitted: 2022-01-27
• Last Update Posted: 2022-01-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Clinically diagnosed as idiopathic Parkinson's disease
• Modified Hoehn & Yahr stage 2, 2.5, or 3

Exclusion Criteria

• Moderate to severe cognitive dysfunction with Mini-mental State Examination score < 19
• Severe dyskinesia or severe on-off phenomenon
• Plan to adjust medication at the time of screening
• Other brain diseases such as stroke, brain tumor, etc
• History of seizure
• Vestibular disease or paroxysmal vertigo
• Other comorbidities that make it difficult to participate in this study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Virtual reality exergames	Virtual reality exergames	Cognitively challenging exergames using fully immersive virtual reality with a head-mounted display (HTC Vive; HTC Co., New Taipei City, Taiwan)

Primary Outcome Measures

Name	Time	Method
Cognitive dual-task interference (%) in Timed-up & go test	at study completion, an average of 1 month
Physical dual-task interference (%) in Timed-up & go test	at study completion, an average of 1 month

Secondary Outcome Measures

Name	Time	Method
New Freezing of Gait Questionnaire (NFOGQ)	at study completion, an average of 1 month
Trail making test	at study completion, an average of 1 month
Timed-up & go test (sec): single task	at study completion, an average of 1 month
Berg balance scale	at study completion, an average of 1 month	The higher the score, the more positive the result
Timed-up & go test (sec): cognitive dual-task	at study completion, an average of 1 month
The Unified Parkinson's Disease Rating Scale	at study completion, an average of 1 month	The higher the score, the more negative the result
Stroop test	at study completion, an average of 1 month
Digit span test	at study completion, an average of 1 month
Timed-up & go test (sec): physical dual-task	at study completion, an average of 1 month

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of