NL-OMON40596已完成2 期
Effects of ivabradine on vascular function in individuals at increased risk of developing cardiovascular disease and with impaired endothelial function;An international, multicentre, randomised, double-blind, placebo-controlled study over 12 weeks. - Effects of ivabradine on vasular function
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 200
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •- Men or postmenopausal women of any ethnic origin aged between 21 and 74 years
- •- In sinus rhythm with resting HR at least 75 bpm
- •- At increased risk of subsequent cardiovascular disease (documented by the presence of at least two cardiovascular risk factors such as diabetes, hypertension, smoking, hypercholesterolemia) and impaired FMD * 5.0 %
排除标准
- •- Previous diagnosis of coronary heart disease
- •- Previous diagnosis of heart failure or current clinical signs or symptoms in keeping with a diagnosis of heart failure
- •- History of cerebrovascular or peripheral arterial disease
- •- Uncontrolled hypertension
- •- Chronic infectious or inflammatory disease
- •- Chronic Obstructive Pulmonary Disease (COPD) treated with inhaled bronchodilators
- •- Malignancy
- •- Current therapy with nicorandil, nitrate, insulin
- •- Contra-indication to ivabradine
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