Effect of Allogeneic Adipose Tissue-Derived Mesenchymal Stem Cell Transplantation on SLE
Phase 1
- Conditions
- Severe and Refractory Lupus Nephritis.Systemic lupus erythematosus with organ or system involvement
- Registration Number
- IRCT2016090729747N1
- Lead Sponsor
- Council for Stem Cell Sciences and Technologies
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Criteria for entrance to the study: Criteria for entrance to the study include increase in proteinuria (defined as more than 1.0 g of protein excretion in a 24-h urine specimen), Systemic lupus erythematosus disease activity index of more than 8 (All patients were resistant to at least 3 months of therapy with conventional treatment standard).
Exclusion criteria:
uncontrolled infection, failure of kidney or other vital organs, pregnancy or lactating.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Proteinuria. Timepoint: 1 week, 1, 3, 6, 9 and 12 months. Method of measurement: clinical tests.;Glomerular filtration rate. Timepoint: 1 week, 1, 3, 6, 9 and 12 months. Method of measurement: clinical tests.
- Secondary Outcome Measures
Name Time Method Systemic lupus erythematosus disease activity index score. Timepoint: 1 week, 1, 3, 6, 12 and 18 months. Method of measurement: clinical tests.