Effect of Ketone Esters Ingested During Recovery on Metabolism and Subsequent Exercise Capacity
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Glucose concentrations
研究概览
简要总结
Infusion of beta-hydroxybutyrate can suppress endogenous glucose production, which may result in increased net liver glycogen storage. If ketone esters exert similar effects, then the increase in liver glycogen storage may have implication for recovery from exercise and subsequent exercise performance.
The aim of this study is to assess the effects of ketone esters ingested during recovery from exercise, on metabolism and subsequent exercise capacity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •VO2max ≥ 45mL.kg-1.min-1
- •Weekly aerobic training > 3hours.
- •2years running experience.
- •BMI < 30kg/m2
排除标准
- •<18yrs or >60yrs of age
- •Habitual smoker within last 5 years.
- •History of uncontrollable metabolic or respiratory disease.
- •Currently taking medication, following a low carbohydrate or ketogenic diet, or consuming nutritional ketone supplements.
- •History of Irritable Bowel Syndrome
研究组 & 干预措施
PLACEBO
Energy matched placebo containing medium-chain triglycerides and bitter taste
干预措施: Placebo (Dietary Supplement)
KETONE
Beta-hydroxybutyrate monoester
干预措施: Ketone ester (Dietary Supplement)
结局指标
主要结局
Glucose concentrations
时间窗: 240 minutes
Blood glucose concentrations during the recovery period (240 minutes)
次要结局
- Non-oxidative fate of ingested sucrose(240 minutes)
- Exercise capacity(240 minutes)
研究者
Javier Gonzalez
Professor of Nutrition and Metabolism
University of Bath