Effect of dexamethasone on the onset time and recovery profiles of cisatracurium

Not Applicable

Completed

Conditions: Not Applicable

Registration Number: KCT0001519

Lead Sponsor: Chosun University Hospital

Brief Summary: we enrolled 117 patients who were required 39 patients in each group. Eighty patients were ultimately enrolled in this study. Thirty-seven patients (9 patients in group A, 11 patients in group B, and 17 patients in control group[group C]) were excluded from the data analysis because their clinical duration and recovery index were not calculated owing to below 75% T1 depression. No significant differences in sex, ASA physical status, age, height, weight, and BMI were found among the groups. The one-way ANOVA analysis and Kruskal-Wallis test showed significant differences among groups in the onset, recovery, and total recovery times. However, there were no significant differences in the clinical duration and recovery index among groups. The onset time was significantly hastened in group A compared to that in group B and C. The onset time in group B was also faster than control group. The recovery time was significantly hastened in group A compared to that in group B and control group. However, we found no significant difference between group B and the control group. The total recovery time was significantly hastened in group A compared to that in group B and control group . However, we found no significant difference between group B and the control group. The incidence of incomplete neuromuscular block was not significantly different among the groups.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 117

Inclusion Criteria

Patients who are scheduled to undergo elective surgery under general anesthesia

Exclusion Criteria

A. Patients who do not sign a written informed consent
B. Patients with uding of steroid medication within the last 24 hours
C. Patients who receving medication known to infulence neuromuscular function such as furosemide, magnesium or cephalosporin
D. Patients with neuromuscular disease, diabetics, receving chronic steroid medication due to cheonic disease
E. expected difficult mask ventilation or intubation
F. with an allergy to cisatracurium and dexmethasone
G. pregnant , breastfeeding women, or women who Will be getting pregnant
H. BMI > 25%
I. Aged under 20 or over 65 years