Intravenous Administration of Insulin and Plasma Exchange on Triglyceride Levels in Early Stage of Hypertriglyceridemia-induced Pancreatitis
- Registration Number
- NCT03342807
- Lead Sponsor
- Peking Union Medical College Hospital
- Brief Summary
To investigate an economical and effective way to reduce the level of serum triglyceride in patients with hypertriglyceridemia-induced acute pancreatitis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 220
Inclusion Criteria
- Adult aged 18 to 80 years old;
- abdominal pain consistent with AP;
- serum amylase and / or lipase activity is at least 3 times higher than the normal upper limit;
- abdominal imaging consistent with AP imaging changes.
- severe hyperlipidemia "fasting serum TG> 1,000 mg/dL (11.2mmol/L)";
- except for other AP causes, such as cholelithiasis, alcohol, drugs and so on.
Exclusion Criteria
- other etiologies other than hyperlipidemia leading to AP;
- fasting serum TG less than 1,000 mg / dL (11.2mmol / L);
- acute lipid-induced pancreatitis at the same time combined with other etiologies of acute pancreatitis.
- the existence of plasma replacement contraindications: serious allergies to plasma, human serum albumin, heparin and others; the existence of mental disorders; unstable heart or cerebral infarction; intracranial hemorrhage or severe cerebral edema associated with hernia.
- without informed consent, the patient refused to plasma replacement, and other circumstances may bring significant bias.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group Insulin Insulin - Group Aphesis Aphesis -
- Primary Outcome Measures
Name Time Method serum TG every 4 hours in first 3 days Elimination of serum triglyceride.
- Secondary Outcome Measures
Name Time Method