Effectiveness of cognitive intervention on subjective cognitive decline in patients with migraine on psychophysiological outcomes

According to WHO, Migraine is a primary headache disorder, in most cases episodic, that

usually lasts 4–72 hours, accompanied by nausea, vomiting and/or photophobia and

phonophobia. It is sometimes preceded by a short-lasting aura of unilateral, reversable

visual, sensory or other symptoms. Migraine is a complex neurological condition with a

genetic basis, marked by recurring episodes of moderate to severe headaches. These

headaches are often localized to one side of the head and are commonly associated with

nausea, as well as increased sensitivity to light and sound. Subjective cognitive decline

(SCD) refers to self-perceived worsening of cognitive abilities, such as memory and

attention, without objective evidence from cognitive testing. In individuals with migraine,

SCD is notably prevalent and appears to be closely linked with comorbid conditions like

depression, anxiety, and poor sleep quality. A comparative study design is proposed to be

conducted in subjective cognitive decline in patients with migraine. Individuals with

clinically diagnosed migraine without aura (ICHD-3), more than 4 attacks over the past 3

months, more than 1-year migraine history, SCD-Q score more than 5, excluding other

headache types, neurological/endocrine conditions, pregnancy, or recent cognitive training.

Ethical clearance will be obtained from Institutional ethical committee before

commencing the project. After receiving the informed consent form, the subjects will be

screened for subjective cognitive decline. The screened patients will be allocated in 3

groups: Each group will be for 3 times per week for 6 weeks.