Resistance Training and Sex Hormone Concentrations During the Menstrual Cycle

Not Applicable

• Conditions: Women's Health
• Interventions: Behavioral: Resistance Training

• Registration Number: NCT04163380
• Lead Sponsor: Southern Illinois University Edwardsville

Brief Summary

Although there are numerous studies showing effects of aerobic training on sex hormone concentrations, research analyzing the fluctuation of sex hormones in response to resistance training (RT) is lacking. The objective of this project is to analyze estradiol (E2) and progesterone (P4) responses to an acute resistance training session throughout different phases of the menstrual cycle. This proposed research has strong implications for exercise prescription and for women in general, but more importantly will allow exercise physiologists, coaches, personal trainers, or nutritionists optimize exercise programming around women's menstrual cycle.

Detailed Description

Not available

Study Timeline

• Status Verified: 2019-05
• Study First Submitted: 2019-10-30
• Study Start: 2019-11-01
• Study First Submitted QC: 2019-11-13
• Study First Posted: 2019-11-14
• Last Update Submitted: 2020-02-15
• Last Update Posted: 2020-02-18
• Primary Completion: 2021-12
• Study Completion: 2021-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 25

Inclusion Criteria

• Eumenorrheic females
• Age 18-45 years old
• BMI of 18.5-34.99 kg/m2

Exclusion Criteria

• Practice exercise more than 2 days/week in the last 3 months.
• Cardiovascular, metabolic, pulmonary or muscular-skeletal condition
• Taking medications that affect metabolism (e.g. oral contraceptives)
• Irregular menstrual cycles

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Early Follicular Phase (EFP)	Resistance Training	-
Late Follicular Phase (LFP)	Resistance Training	-
Late Luteal Phase (LLP)	Resistance Training	-
Early Luteal Phase (ELP)	Resistance Training	-

Primary Outcome Measures

Name	Time	Method
Change in progesterone concentrations	through study completion, an average of 5 weeks	Progesterone concentrations will be obtained from blood samples assessed using through ELISA kits
Change in estrogen concentrations	through study completion, an average of 5 weeks	Estrogen concentrations will be obtained from blood samples assessed using through ELISA kits

Secondary Outcome Measures

Name	Time	Method
Lean body mass (kg)	At baseline: 1 assessment point	Lean body mass (kg) will be assessed through Dual-energy X-ray Absorptiometry
Fat mass (kg)	At baseline: 1 assessment point	Fat mass (kg) will be assessed through Dual-energy X-ray Absorptiometry
Relative body fat (%)	At baseline: 1 assessment point	Relative body fat (%) will be assessed through Dual-energy X-ray Absorptiometry
Strength in Leg Press	At baseline: 1 assessment point	Maximal strength in leg press will be assessed using one repetition maximum test
Cardiorespiratory Fitness	At baseline: 1 assessment point	Cardiorespiratory Fitness will be assessed with a cardiopulmonary exercise test using the Bruce protocol
Strength in Bench Press	At baseline: 1 assessment point	Maximal strength bench press will be assessed using one repetition maximum test
Changes in diet	through study completion, an average of 5 weeks	Diet will be assessed using the a 24h dietary recall
Skeletal muscle mass (kg)	At baseline: 1 assessment point	Skeletal muscle mass (kg) will be estimated using Dual-energy X-ray Absorptiometry values

Trial Locations

Locations (1)

Southern Illinois University Edwardsville; 🇺🇸 Edwardsville, Illinois, United States