Lung Recruitment Assessed by Two-Dimensional/Three-Dimensional Electrical Impedance Tomography and Recruitment-to-Inflation Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation
Overview
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Lung recruitment assessed by R/I ratio and 2D/3D-EIT （PEEP titration）
Overview
Brief Summary
The purpose of this observational study is to assess the differences and consistency in evaluating lung recruitment potential between the recruitment-to-inflation ratio (R/I ratio) and three-dimensional electrical impedance tomography (3D-EIT) and two-dimensional EIT (2D-EIT) in mechanically ventilated patients with acute respiratory failure. The main questions it aims to answer is:
Are the lung recruitment potentials predicted by 3D-EIT, 2D-EIT and the R/I ratio consistent? Participants will: Undergo a standardized PEEP titration protocol with synchronized EIT monitoring; Have R/I ratios measured at high and low PEEP levels.
Study Design
- Study Type
- Observational
- Observational Model
- Case Only
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing.
- •Oxygenation index \< 300 mmHg.
- •Patients who are clinically judged by the attending doctor to require the PEEP titration.
Exclusion Criteria
- •Aged under 18 years.
- •Pregnancy.
- •Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others).
- •No informed consent obtained.
- •Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor.
- •High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.
Arms & Interventions
Mechanically ventilated patients with hypoxemia requiring clinical PEEP optimization
The study will enroll mechanically ventilated patients under sedation/analgesia without spontaneous breathing, exhibiting a oxygenation index (PaO₂/FiO₂ ratio) <300 mmHg, and deemed clinically eligible for PEEP titration by attending physicians.
Intervention: The lung recruitment potential assessed and PEEP titration by ventilator and 2D/3D EIT (Diagnostic Test)
Outcomes
Primary Outcomes
Lung recruitment assessed by R/I ratio and 2D/3D-EIT （PEEP titration）
Time Frame: Within 24 hours post-enrollment
Lung recruitment potential can be predicted by the R/I ratio and the lung collapse rate calculated from 2D/3D-EIT.
Secondary Outcomes
No secondary outcomes reported