Effect of Premedication on Pain Perception: functional Magnetic Resonance Imaging (fMRI) study of healthy volunteers

Completed

• Conditions: Pain perception; Signs and Symptoms; Pain

• Registration Number: ISRCTN61356305
• Lead Sponsor: niversity Hospital Centre of Angers (Centre Hospitalier Universitaire d'Angers) (France)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-02-19
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 17

Inclusion Criteria

1. Informed consent
2. Right handed
3. American Society of Anaesthesiology (ASA) classification I or II
4. No chronic drug therapy
5. No MRI contraindication
6. Accept the interdiction to drive car and drink alcohol until next morning
7. Aged 25 - 65 years, either sex

Exclusion Criteria

1. Myasthenia
2. Hypersensibility to midazolam and hydroxyzine
3. MRI contraindication

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Volume of central pain matrix activation on fMRI, obtained by contrasting painful stimulation period with resting state period during fMRI recording.

Secondary Outcome Measures

Name	Time	Method
Visual analogic pain score, measured at the end of each 6 seconds painful stimulation period.