NCT00738842已完成1 期
A Randomised, Double-Blind, Two-Period Crossover Study to Assess the Effect of AZD6140 on Uric Acid Levels in Healthy Male Volunteers
适应症
干预措施
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- AstraZeneca
- 入组人数
- 24
- 主要终点
- The effect of AZD6140 on the levels of certain chemicals in subjects' blood and urine.
研究概览
简要总结
This study is being conducted to examine the effect of AZD6140 on the levels of certain chemicals in subjects' blood and urine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Normal physical examination, vital signs, electrocardiogram (ECG) and laboratory values (unless the investigator considers an abnormality not to be clinically significant)
- •Normal laboratory tests at screening
- •Non-smoker (no cigarette/tobacco use for at least 6 months)
排除标准
- •Personal or family history of gout, gouty arthritis, or renal stones
研究组 & 干预措施
1
Experimental
干预措施: AZD6140 (Drug)
2
Placebo Comparator
干预措施: Placebo to match AZD6140 (Drug)
结局指标
主要结局
The effect of AZD6140 on the levels of certain chemicals in subjects' blood and urine.
时间窗: Levels or certain chemicals in subjects' blood and urine will be measured at scheduled times during the first 7 days of the study.
次要结局
- The blood levels of AZD6140 in various subjects on the same diet.(following dosing during the first 5 days of the study)
- The effect of taking AZD6140 on the levels of certain hormones in urine(during the first 5 days of the study)
研究者
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