Joint Use of Electrocardiogram and Transthoracic Echocardiography With Other Clinico-biological Parameters in an Observational Study to Monitor Cardio-vascular Events and Predict Outcomes in Patients Diagnosed With COVID-19
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- COVID-19
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
- Enrollment
- 500
- Locations
- 1
- Primary Endpoint
- Incidence of acute myocardial events in COVID-19 population at baseline and during hospital stay
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
COVID-19 outbreak is often lethal. Mortality has been associated with several cardio-vascular risk factors such as diabetes, obesity, hypertension and tobacco use. Other clinico-biological features predictive of mortality or transfer to Intensive Care Unit are also needed. Cases of myocarditis have also been reported with COVID-19.
Cardio-vascular events have possibly been highly underestimated. The study proposes to systematically collect cardio-vascular data to study the incidence of myocarditis and coronaropathy events during COVID-19 infection.We will also assess predictive factors for transfer in Intensive Care Unit or death.
Investigators
Joe Elie Salem
Head of Investigations in Clinical Investigation Centers Paris-Est
Groupe Hospitalier Pitie-Salpetriere
Eligibility Criteria
Inclusion Criteria
- •COVID-19 positive patients admitted in a ward identified by positive PCR on nasal swab samples
Exclusion Criteria
- •Patients who refused the use of their routine care data after information by investigators.
Outcomes
Primary Outcomes
Incidence of acute myocardial events in COVID-19 population at baseline and during hospital stay
Time Frame: ECG and concomitant troponine at day 1 after admission at day 1, day 3 day 6 the first week after admission, and then at day 14 and before the patient is discharged (up to 20 days)
Viral myocarditis or myocardial infarction or stenosis detected with ST segment elevation or depression associated with troponine elevation and transthoracic echocardiography
Secondary Outcomes
- Characterization of inflammation on cardio-vascular outcomes(Baseline and at day 3 day 6 day 14 and before patient is discharged (up to 20 days))
- Prognosis role of baseline cardio-vascular caracteristics on patients survival(1st day of admission)
- Description of cardiovascular outcomes in the cohort(During hospital admission (up to 20 days))
- Prediction of cardio-vascular events with baseline characteristics(Baseline on first day of admission)
- Prognosis role of baseline clinico-biological caracteristics on patients transfer to ICU and survival(Baseline and at day 3 day 6 day 14 and before patient is discharged (up to 20 days))