Treatment of posttraumatic neuralgia - Changes in central pain processing and somatosensory profile after injection of Botulinumtoxin-A compared to placebo
Phase 2
- Conditions
- posttraumatic neuropathic pain after peripheral nerve leasion
- Registration Number
- DRKS00013548
- Lead Sponsor
- Abteilung für SchmerzmedizinBerufsgenossenschaftliches Universitätklinikum Bergmannsheil gGmbH Bochum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting withdrawn before recruiting started
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
Diagnosis of painful neuralgia after peripheral nerve injury, average pain > 4 on numeric rating scale (0-10) in the last two weeks, evidence for nerve leasion (current/anamnestic)
Exclusion Criteria
Age > 18 years, pregnancy, contraindications against injection or FMRI, other neurological or psychiatric diseases, CRPS (Complex regional pain syndrome)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of patients with relevant pain reduction (50%) within one week after injection of Botulinumtoxin-A in comparison to placebo with pain diaries, pain questionnaires, quantitative sensory testing, fMRI, conditioned pain modulation
- Secondary Outcome Measures
Name Time Method Extent of the avergae pain reduction, changes in peripheral sensory system, central pain modulation with pain diaries, pain questionnaires, quantitative sensory testing, fMRI, conditioned pain modulation