Prognosis and Risk Factors for Acute Kidney Injury

Recruiting

• Conditions: Acute Kidney Injury

• Registration Number: NCT06898944
• Lead Sponsor: Seoul National University Hospital

Brief Summary

The aim of our study is to analyze the accurate diagnosis and prognosis of acute kidney injury (AKI) based on its severity and to define long-term clinical and socioeconomic outcomes.

Investigators defined the AKI group among adults aged 20 years or older who visited enrolled center and underwent at least two blood tests, including serum creatinine, within an interval of 7 days or less and a control group was matched 1:1 to the AKI group based on age, sex, year of visit, and baseline kidney function, forming the study population. Investigators then collected and analyzed various clinical, laboratory, and hospitalization records including demographic data, anthropometric data, laboratory data, and medical history.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-08-22
• Status Verified: 2025-03
• Study First Submitted: 2025-03-20
• Study First Submitted QC: 2025-03-20
• Study First Posted: 2025-03-27
• Last Update Submitted: 2025-03-28
• Last Update Posted: 2025-04-02
• Primary Completion: 2026-12-31
• Study Completion: 2026-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 320000

Inclusion Criteria

• Adults over 20 years old who visited Parcitipating Medical Center (Seoul National University Hospital, Bundang Seoul National University Hospital, SMG-SNU Boramae Medical Center, Keimyung University Dongsan Medical Center) between 2006 and 2021
• The AKI group is defined as individuals meeting the AKI diagnostic criteria of the KDIGO Guideline (an increase in serum creatinine of ≥0.3 mg/dL or ≥1.5 times the baseline level) is enrolled.
• The Control Group is defined as individuals from the study population who do not meet the AKI criteria and are matched 1:1 based on age, sex, year of visit, and baseline renal function.

Exclusion Criteria

• Individuals under 20 years old
• Individuals who did not undergo serum creatinine tests meeting the criteria
• Individuals with pre-existing end-stage kidney disease (ESKD) who have undergone dialysis or kidney transplantation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change from Baseline in Serum Creatinine	From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date

Secondary Outcome Measures

Name	Time	Method
Change from Baseline in Urine Protein/Creatinine Ratio	From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date
Incidence of Receiving Renal Replacement Therapy	From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date
Change from Baseline in Serum Hemogloblin Level	From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date
Change from Baseline in Serum Albumin Level	From Index Date(The Date Which Acute Kidney Injury Occured) Through 5 Years After The Index Date

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of