NCT01629745已完成不适用
Feasibility of Minimal Residual Disease (MRD) Determination in Pediatric B-Lineage ALL Using Deep Sequencing of the Immunoglobulin Heavy Chain Locus
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 99
- 主要终点
- Sensitivity of deep sequencing of the immunoglobulin heavy chain locus in determining MRD in B-lineage ALL
研究概览
简要总结
RATIONALE: Testing for minimal residual disease in blood samples from patients with acute lymphoblastic leukemia may help doctors plan better treatment.
PURPOSE: This research trial studies a genetic test in detecting minimal residual disease in samples from younger patients registered on COG-AALL08B1 trial.
详细描述
OBJECTIVES:
- Assess the feasibility of minimal residual disease (MRD) determination in pediatric B-lineage acute lymphoblastic leukemia (ALL) using deep sequencing of the immunoglobulin heavy chain locus.
OUTLINE: Archived blood and tumor tissue samples are analyzed for MDR using deep sequencing of immunoglobulin heavy chain locus. MDR quantification results are then compared with the flow cytometry reference methods used in COG studies.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- — 至 30 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Sensitivity of deep sequencing of the immunoglobulin heavy chain locus in determining MRD in B-lineage ALL
次要结局
未报告次要终点
研究者
相似试验
已完成
不适用
Assessment of Minimal Residual Disease (MRD) After Antineoplastic Treatment in Patients With AL AmyloidosisAmyloidosisNCT02716103Boston Medical Center45
Unknown
不适用
New Markers for Minimal Residual Disease in Acute Lymphoblastic LeukemiaAcute Lymphoblastic LeukemiaNCT03249636Assiut University50
已完成
不适用
Genetic Test To Identify Previously Undetectable Minimal Residual Disease in Cell Samples From Younger Patients With Acute Lymphoblastic LeukemiaLeukemiaNCT01533168Children's Oncology Group12
已完成
不适用
MRD Testing Before and After Hematopoietic Cell Transplantation for Pediatric Acute Myeloid LeukemiaAcute Myeloid LeukemiaNCT01385787Center for International Blood and Marrow Transplant Research150
招募中
3 期
A Prospective Multicenter Clinical Trial of MRD-based Treatment Strategy in Children and Young Adults With AMLAcute Myeloid Leukemia, ChildhoodNCT03846362Federal Research Institute of Pediatric Hematology, Oncology and Immunology500