Comparison of Single-syringe vs. Double-syringe Techniques for Adenosine Administration in Supraventricular Tachycardia: A Randomized Clinical Trial
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 131
- 试验地点
- 1
- 主要终点
- First-dose successful termination of PSVT
研究概览
简要总结
The purpose of the study is to compare the effectiveness of two different methods of administering adenosine for the treatment of stable supraventricular tachycardia (SVT).
详细描述
The American Heart Association 2015 guidelines recommend adenosine for non-hypotensive patients with regular narrow complex SVT. Adenosine is usually given as a rapid intravenous bolus of 6mg over 1-2 seconds, followed by a 20ml saline flush. If the first dose does not result in the termination of SVT to normal sinus rhythm (NSR) within 1-2 minutes, a repeat dose of 12mg can be given, and the dose may be repeated one more time, if necessary, for a total of three doses.
The double-syringe technique (DST) is the standard method for administering adenosine. However, recent studies suggest that the single-syringe technique (SST) may be simpler and potentially beneficial. This technique injects adenosine and saline simultaneously at the same time instead of two separate injections. The study aims to determine if the SST method is non-inferior to the DST method.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18 to 80 years
- •Presentation to the emergency department with narrow-QRS tachyarrhythmia
- •Heart rate ≥150 beats/min
- •No visible P wave or presence of retrograde P wave on ECG
- •Not responsive to Valsalva maneuvers lasting 15 to 30 seconds
- •Requiring adenosine administration
排除标准
- •Wide-QRS tachycardia or irregular R-R interval on ECG
- •Known allergy or contraindication to adenosine
- •Recent ingestion of dipyridamole, carbamazepine, or theophylline
- •Caffeine ingestion within the previous 2 hours
研究组 & 干预措施
Single-syringe technique (SST)
干预措施: Single-syringe Adenosine (Drug)
Double-syringe technique (DST)
干预措施: Double Syringe Adenosine (Drug)
结局指标
主要结局
First-dose successful termination of PSVT
时间窗: Within 2 minutes after administration of the first dose of adenosine.
Proportion of participants with conversion from paroxysmal supraventricular tachycardia to sinus rhythm after the first dose of adenosine.
次要结局
- Total administered dose of adenosine.(From administration of the first dose until successful termination of PSVT or up to 10 minutes, whichever occurs first.)
研究者
Farima Roshanasan
Emergency Medicine Resident
Hormozgan University of Medical Sciences