Smoking While on Transdermal Nicotine Replacement Therapy: Effects on Craving and Cessation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Carbon Monoxide Levels
研究概览
简要总结
Smoking while on nicotine patches will help subjects to reduce their expired carbon monoxide levels from the levels they were before they started using the patch. Subjects will also decrease their daily consumption of cigarettes.
详细描述
Subjects who smoke while on an individually dosed tNRT will reduce their expired carbon monoxide levels from pre- to post-treatment conditions. They will also decrease their daily consumption of cigarettes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •at least 19 years of age
- •male or female
- •have intention to quit smoking within the next 6 months
- •smoke 10 or more cigarettes per day
排除标准
- •Pregnant or not using an adequate enough method of birth control to ensure that they are not at risk of becoming pregnant
- •breastfeeding
- •have any generalized skin disorders
- •are in an immediate post-myocardial infarction period or have life-threatening arrhythmias, have severe or worsening angina pectoris or have had a recent cerebral vascular accident
- •are using additional nicotine replacement therapies or any other smoking cessation pharmacotherapy
- •any clinically significant ECG abnormalities
- •any known hypersensitivity to components of the transdermal system
研究组 & 干预措施
single open-label treatment arm
Adult smokers willing to quit were treated with escalating doses of transdermal nicotine patch (Nicoderm) and brief counselling if they continued to smoke over a 9-week treatment period.
干预措施: Nicoderm (Drug)
结局指标
主要结局
Carbon Monoxide Levels
时间窗: measured at week 10
Expired Co levels were measured to confirm smoking status
次要结局
- Smoking Cessation(Week 10)
研究者
Dr. Peter Selby
Dr. P. Selby
Centre for Addiction and Mental Health