Progressive Resistance Exercise in Rheumatoid Arthritis

Phase 4

Completed

• Conditions: Rheumatoid Arthritis
• Interventions: Other: Control group; Other: Experimental group

• Registration Number: NCT02219022
• Lead Sponsor: Federal University of São Paulo

Brief Summary

A randomized controlled trial with rheumatoid arthritis patients will be realized. Patients will be randomized into two groups. Experimental group will do a 12 weeks training of progressive resistance exercise for global muscles and remain with the clinical treatment and the control only remain with the clinical treatment. Patients will be evaluated at baseline, after 6, 12 and 24 weeks.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-07
• Study First Submitted: 2014-08-13
• Study First Submitted QC: 2014-08-14
• Study First Posted: 2014-08-18
• Primary Completion: 2015-06
• Study Completion: 2015-10
• Status Verified: 2016-08
• Last Update Submitted: 2016-08-12
• Last Update Posted: 2016-08-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Rheumatoid arthritis according to American College of Rheumatology 2010
• Both genders
• Age between 18 and 65 years
• Functional class I, II and III
• Stable medication within the three months preceding the study
• Haven't done any kind of regular exercise (two or more times per Week) for at least three months before study start
• Have agreed to participate in the study and signed an informed consent form.

Exclusion Criteria

• Participating in another type of study
• Have difficulty understanding the evaluation tools with fibromyalgia
• Joint deformities that make impossible do the exercises
• Other musculoskeletal diseases
• Other diseases that contraindicate exercises.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Control group	Control group	Patient remain with their usual clinical treatment.
Experimental group	Control group	Patients in experimental group participated in a 12-week progressive resistance training using a maximum repetition exercise in which patients performed 1 Maximum Repetition with the maximum bearable weight. Once the 1 Maximum Repetitionwas determined, training was divided into the following regimen: 2 series of 8 repetitions, the first with 50% and the second with 70% of 1 Maximum Repetition. The exercises were knee extension and flexion and hip abduction and adduction, elbow extension and flexion, wrist extension and flexion and shoulder abduction and adduction and spine extension and flexion all performed in machines. The 1 Maximum Repetition load was reevaluated every 6 weeks. Patient remain with their usual clinical treatment.
Experimental group	Experimental group	Patients in experimental group participated in a 12-week progressive resistance training using a maximum repetition exercise in which patients performed 1 Maximum Repetition with the maximum bearable weight. Once the 1 Maximum Repetitionwas determined, training was divided into the following regimen: 2 series of 8 repetitions, the first with 50% and the second with 70% of 1 Maximum Repetition. The exercises were knee extension and flexion and hip abduction and adduction, elbow extension and flexion, wrist extension and flexion and shoulder abduction and adduction and spine extension and flexion all performed in machines. The 1 Maximum Repetition load was reevaluated every 6 weeks. Patient remain with their usual clinical treatment.

Primary Outcome Measures

Name	Time	Method
Change in pain - Visual analogue scale	baseline, 6, 12 and 24 weeks

Secondary Outcome Measures

Name	Time	Method
Change in quality of life - Short form 36	baseline, after 6, 12 and 24 weeks
Change in strength - 1 maximum repetition	baseline, after 6, 12 and 24 weeks
Change in function capacity - Health Assessment questionaire	Baseline, after 6, 12 and 24 weeks

Trial Locations

Locations (1)

Universidade Federal de Sao Paulo; 🇧🇷 Sao Paulo, SP, Brazil