NCT00219817已完成2 期
Safety and Efficacy of RC-1291 HCl in Patients With Cancer Related Anorexia and Weight Loss
适应症
相关药物
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 13
- 主要终点
- Body Weight
研究概览
简要总结
Anorexia and weight loss are devastating complications in late-stage cancer patients and is strongly associated with mortality in these patients. Activation of Ghrelin receptors have been demonstrated to stimulate appetite. RC-1291 HCl, by virtue of its ghrelin like activity and Growth Hormone releasing effects may have a dual role in the reversal of cancer induced anorexia and weight loss. This study will test the safety and efficacy of RC-1291 in the treatment of cancer patients with anorexia and weight loss.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Community-dwelling patients ≥ 18 years of age with incurable, histologically diagnosed cancer.
- •Involuntary loss of body weight of ≥ 5 % within the past 6 months
排除标准
- •Presently hospitalized or in a nursing care facility.
- •Inability to increase food intake from secondary causes.
- •Liver disease
- •If female-pregnant, breast-feeding or of childbearing potential.
结局指标
主要结局
Body Weight
Lean Body Mass
Functional Performance
次要结局
未报告次要终点
研究者
研究点 (13)
Loading locations...
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