Dual Trigger Versus Booster Dose of HCG
Not Applicable
Completed
- Conditions
- Infertility
- Interventions
- Procedure: IVF/ICSI
- Registration Number
- NCT02397642
- Lead Sponsor
- Cairo University
- Brief Summary
To salvage the luteal phase and improve pregnancy rate in antagonist IVF/ICSI cycles triggered with GnRH agonist. Two strategies are compared dual trigger with GnRH agonist plus 1000 IU of HCG or triggering with GnRH and giving a booster dose of HCG (1500 IU) on the day of ovum pickup.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 200
Inclusion Criteria
- High responder females undergoing antagonist protocol IVF/ICSI cycle
- More than 14 MII oocytes
- Estradiol more than 3500 pg/ml on day of trigger
Exclusion Criteria
- Any other protocol
- Normal or poor responders
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Dual trigger IVF/ICSI GnRH agonist plus 1000 IU of HCG to trigger final maturation Booster HCG dose IVF/ICSI GnRH agonist only to trigger final maturation followed by a booster dose of 1500 IU of HCG on the day of ovum pickup Dual trigger Human Chorionic Gonadotropin GnRH agonist plus 1000 IU of HCG to trigger final maturation Booster HCG dose Human Chorionic Gonadotropin GnRH agonist only to trigger final maturation followed by a booster dose of 1500 IU of HCG on the day of ovum pickup
- Primary Outcome Measures
Name Time Method Clinical pregnancy rate 1 year The number of cycles with a evidence of a gestational sac with fetal pulstaions after 5 weeks from pregnancy test
- Secondary Outcome Measures
Name Time Method OHSS rate 1 year The number of cycles with evidence of OHSS
Trial Locations
- Locations (3)
Adam International hospital
🇪🇬Giza, Egypt
Nile IVF center
🇪🇬Giza, Egypt
IVF centre, Obstetrics and Gynaecology Department, Cairo University Hospitals (Kasr EL Aini)
🇪🇬Cairo, Egypt