NCT01503645Unknown不适用
Epidemiology of Chinese Herb Nephropathy and Its Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 200
- 试验地点
- 2
研究概览
简要总结
- Chinese herb nephropathy (CHN), a kind of kidney failure caused by Chinese herbs, may be related to the a component called aristolochic acid (AA).
- AA may form AA-DNA adducts and accumulate in the kidney and ureter and cause kidney failure and/or cancer
- Different enzymes have been reported to detoxify plant alkaloids or other components. Genes that regulate the production of these metabolic enzymes may affect the chance of CHN.
- By comparing the differences in the polymorphisms of these genes between patient with CHN and control, we may find the changes that play a significant genetic factors for CHN.
研究设计
- 研究类型
- Observational
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patient with suspected Chinese herb nephropathy, and their family Control group match for sex age and geographic area (with or without herabla use)
排除标准
- 未提供
研究者
研究点 (2)
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