Chinese Herb Nephropathy Epidemiology and Association With CYP2D6, CYP2C19, PXR, or MDR1 Polymorphism

• Conditions: Kidney Diseases

• Registration Number: NCT01503645
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

1. Chinese herb nephropathy (CHN), a kind of kidney failure caused by Chinese herbs, may be related to the a component called aristolochic acid (AA).

2. AA may form AA-DNA adducts and accumulate in the kidney and ureter and cause kidney failure and/or cancer

3. Different enzymes have been reported to detoxify plant alkaloids or other components. Genes that regulate the production of these metabolic enzymes may affect the chance of CHN.

4. By comparing the differences in the polymorphisms of these genes between patient with CHN and control, we may find the changes that play a significant genetic factors for CHN.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-05
• Status Verified: 2012-01
• Study First Submitted: 2012-01-02
• Study First Submitted QC: 2012-01-03
• Study First Posted: 2012-01-04
• Last Update Submitted: 2012-11-12
• Last Update Posted: 2012-11-14

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Patient with suspected Chinese herb nephropathy, and their family Control group match for sex age and geographic area (with or without herabla use)

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Exclusion Criteria

Not provided

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (2)

Far Estern Memorial Hospital; 🇨🇳 Pan-Chiao, Taipei, Taiwan

National Taiwan University Hospital; 🇨🇳 Taipei, Taiwan