Autonomic nervous system and endocrine system response to upper or lower cervical spine mobilization in males with persistent post-concussion symptoms: a proof-of-concept trial

Gerard Farrell0 个研究点目标入组 19 人开始时间: 2022年3月25日最近更新: 2024年4月22日

适应症

试验速览

暂无简介。

•Males with a diagnosis of persistent post-concussion symptoms aged between 19-35 years old who own an iPhone.

•Participants will be excluded if they are:
•-Asymptomatic.
•-Unable to refrain from external treatment (treatment session in person or online) or change in treatment (progression or modification of existing treatment) for three consecutive days, specifically days five to seven (out of eight), so the intervention can be performed, and salivary samples collected (primary outcome).
•-Confounding factors to the outcome measurements. These include; Serious medical or psychiatric disorder; co-morbid musculoskeletal or serious conditions which may confound treatment or anticipated recovery; NSAIDs use; recent steroid injections; currently have an endocrine, central nervous system, cardiovascular, or a mental health disorder; systemic glucocorticoid or cardioactive medication; serotonin-norepinephrine reuptake inhibitors; moderate to severe traumatic brain injury. Note, Participants prescribed with psychotropic medication for treatment of concussion-related symptoms (e.g., headache and migraine) will be permitted to be enrolled in the study provided they are not prescribed serotonin-norepinephrine reuptake inhibitors (e.g., desvenlafaxine, venlafaxine, duloxetine, etc.) given their impact on autonomic function.
•-Contra-indications to the intervention. If any precautions to manual therapy are present, participants will be excluded on a case-by-case basis.

发起方

Gerard Farrell