The effect of orthokeratology contact lens wear on anterior eye stem cells in young healthy myopic adults

Not Applicable

Recruiting

• Conditions: myopia; Eye - Diseases / disorders of the eye

• Registration Number: ACTRN12618000278235
• Lead Sponsor: niversity of New South Wales

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-02-22
• Last Update Posted: 26 July 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

1.Healthy individuals aged between 18-40
2.Have short-sightedness (myopia) between -1.ooD and -6.ooD and less than -1.50D of corneal astigmatism
3.No previous soft or rigid contact lens wear
4.Have good ocular health and general health
5.No contraindications to rigid contact lens wear

Exclusion Criteria

1. Systemic or ocular conditions that may affect tear quality or contact lens wear
2. Previous history of ocular surgery, trauma, or chronic ocular disease
3. Ocular or systemic medication use that may interfere with contact lens wear or ocular surface
4. Previous reactions or allergies to any ocular medications
5. Not willing to comply with the allocated treatment and follow-up schedule

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
imbal stem cell changes measured with a confocal microscope (Heidelberg Retina Tomography III Rodenstock corneal module)[Measurements will be taken at baseline before any lens wear, then after 1, 7 and 14 (primary time point) nights of orthokeratology lens wear.]

Secondary Outcome Measures

Name	Time	Method
Anterior eye shape changes will be measured using the Medmont E300 corneal topographer and Tomey Casia SS-1000 anterior eye optical coherence tomographer.[Measurements will be taken at baseline before any lens wear, then after 1, 7 and 14 nights of orthokeratology lens wear.]