A Pilot Study of a Strategy and Computer-based Intervention to Enhance Daily Cognitive Functioning After Stroke
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stroke
- Sponsor
- Weill Medical College of Cornell University
- Enrollment
- 3
- Locations
- 1
- Primary Endpoint
- Participant impression of ASCEND as a credible treatment to improve cognition, as measured by the Credibility and Expectancy Questionnaire (CEQ).
- Status
- Terminated
- Last Updated
- 2 years ago
Overview
Brief Summary
This is an initial pilot study to test feasibility, participant engagement and satisfaction, and clinical and neurobiological target engagement of a behavioral treatment called "ASCEND" that combines computer-based cognitive training and coaching of cognitive strategies to improve daily cognitive functioning in individuals with stroke.
Investigators
Eligibility Criteria
Inclusion Criteria
- •History of first-time stroke, minimum of 6 months prior to enrollment
- •English speaking
- •Ability to comprehend sufficiently to participate in the treatment.
- •Subjective or objective evidence of mild cognitive impairment
- •Willingness to participate in full study duration
- •Has computer that meets specification for the training program software.
- •Physically able to operate a computer keyboard and mouse.
- •Not concurrently receiving other cognitive rehabilitation services
- •Cognitively able to perform basic self-care activities (e.g., dressing, grooming, eating).
Exclusion Criteria
- •History of neurologic disease other than stroke
- •History of severe mental illness or substance use disorder, or current major depressive episode.
- •History of dementia or dependence in basic self-care activities due to cognitive deficits
- •Contraindications to MRI
Outcomes
Primary Outcomes
Participant impression of ASCEND as a credible treatment to improve cognition, as measured by the Credibility and Expectancy Questionnaire (CEQ).
Time Frame: 5 weeks (at the conclusion of treatment)
The CEQ is a self-report measure that assesses participants' perceived benefit and improvement from the intervention. Each item is scored on a 1-9 Likert-type scale or as a percentage rating from 0% to 100% in 10% increments.
Participant satisfaction with ASCEND, as measured by the Client Satisfaction Questionnaire-8 (CSQ-8)
Time Frame: 5 weeks (at the conclusion of treatment)
The CSQ-8 is a self-report measure of participant satisfaction with the intervention. Scores range from 8-32 with higher scores indicating greater satisfaction.
Secondary Outcomes
- Change in attention and working memory as measured by the Mental Control test(Baseline, 5 weeks)
- Change in visual attention and working memory, as measured by the Symbol Span test(Baseline, 5 weeks)
- Change in divided attention and working memory, as measured by the Symbol-Digit Modalities Test(Baseline, 5 weeks)
- Change in divided attention and processing speed, as measured by the Trail Making Test(Baseline, 5 weeks)
- Change in selective attention and inhibitory control, as measured by the Stroop Test(Baseline, 5 weeks)
- Change in rapid working memory and mental arithmetic, as measured by the Paced Auditory Serial Addition Test (PASAT)(Baseline, 5 weeks)
- Change in auditory attention and working memory, as measured by the Digit Span test(Baseline, 5 weeks)
- Change in self-reported cognitive symptoms due to stroke, as measured by the Patient Reported Evaluation of Cognitive State (PRECIS).(Baseline, 5 weeks)
- Change in executive functioning as measured by the Weekly Calendar Planning Activity(Baseline, 5 weeks)
- Change in self-reported executive functioning as measured by the Behavior Rating Inventory of Executive Function-Adult(Baseline, 5 weeks)