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临床试验/NCT06539650
NCT06539650已完成不适用

Neural Adaptations to a Single Session Metronome-Paced Strength Training: Insights From Neuroscience and Human Movement Variability

Egas Moniz - Cooperativa de Ensino Superior, CRL1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2024年7月22日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
30
试验地点
1
主要终点
Corticospinal Excitability (CSE) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions

研究概览

简要总结

The aim of the study is to investigate the effects of incorporating variability within a single session of Resistance Training (RT) methods on the neural adaptations along the corticospinal tract and on neuromuscular function. The literature suggests that RTis one of the most common modalities to enhance and restore muscle function and its practice results in adaptation in neural and morphological adaptations. Moreover, it is also known that muscle contraction relies on the coordination and regulation of the descending neural drive from the motor cortex to the motoneurons and from the motoneurons to the muscles. However, traditional RT programs tend not to address this motor control dimension. Recent approaches such as metronome paced strength training have been used to cover this motor control dimension through a greater control and consciousness of movement. However, this methodology tends not to incorporate the inherent variability and complex, fractal-like fluctuations that characterize human movement. The investigators propose that incorporating variability through a fractal-like metronome approach will speed up the neural adaptations which will be useful in injury rehab

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • healthy males
  • aged between 18 and 40 years

排除标准

  • Neurologic conditions;
  • Lower limb disabilities or disease;
  • Not able to provide informed consent;
  • Have an implanted device (e.g. pacemakers) or any metal in the body;
  • Medication advised against the application of Transcranial Magnetic Stimulation;
  • History/family history of seizures, brain lesions or head trauma, neurological or psychiatric diseases, epilepsy, migraine

研究组 & 干预措施

Fractal Paced

Experimental

Strength training in single leg extension machine, synchronizing each repetition with a fractal-like visual metronome, i.e., a metronome presenting visual external cues with variability within its temporal structure.

干预措施: Fractal Paced (Other)

Isochronous Paced

Experimental

Strength training in single leg extension machine, synchronizing each repetition with a isochronus visual metronome, i.e., a metronome presenting visual external cues withthe same pace in each repetition (without variability)

干预措施: Isochronus Paced (Other)

Self Paced

Experimental

Strength training in single leg extension machine at participants self pace.

干预措施: Self Paced (Other)

结局指标

主要结局

Corticospinal Excitability (CSE) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions

时间窗: PRE (before intervention), POST (immediately after the intervention) and POST 60 (60 minutes after the intervention)

CSE is a parameter extracted through the application of Transcranial Magnetic Stimulation (TMS). This parameter provides information regarding the level of excitability of the corticospinal tract.

Short-Interval Intracortical Inhibition (SICI) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions

时间窗: PRE (before intervention), POST (immediately after the intervention) and POST 60 (60 minutes after the intervention)

SICI is a parameter extracted through the application of Transcranial Magnetic Stimulation (TMS). This parameter provides information regarding the level of inhibition within the motor cortex.

Corticospinal Silent Period (CSP) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions

时间窗: PRE (before intervention), POST (immediately after the intervention) and POST 60 (60 minutes after the intervention)

CSP is a parameter extracted through the application of Transcranial Magnetic Stimulation (TMS). This parameter provides information regarding the level of inhibition along the corticospinal tract.

Intracortical Facilitation (ICF) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions

时间窗: PRE (before intervention), POST (immediately after the intervention) and POST 60 (60 minutes after the intervention)

ICF is a parameter extracted through the application of Transcranial Magnetic Stimulation (TMS). This parameter provides information regarding the level of facilitation within the motor cortex.

Lumbar Evoked Potentials (LEP) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions

时间窗: PRE (before intervention), POST (immediately after the intervention) and POST 60 (60 minutes after the intervention)

LEP is a measure extracted through the aplication of Lumbar stimulation. This measure allow to distinguish the adaptations that occur at spinal level as a result of strength training.

Maximal Compound Action Potentials (Mmax) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions

时间窗: PRE (before intervention), POST (immediately after the intervention) and POST 60 (60 minutes after the intervention)

Mmax is a measure assessed through peripheral nerve stimulation and represents the maximal capacity of recruit the motoneurons that innerve a muscle

次要结局

  • Maximal Voluntary Isometric Contraction (MVIC) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions(PRE (before intervention), POST (immediately after the intervention) and POST 60 (60 minutes after the intervention))
  • Sample Entropy (SampEn) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions(PRE (before intervention), POST (immediately after the intervention) and POST 60 (60 minutes after the intervention))
  • Coefficient ov variation (CV) changes Pre-to-Post intervention both within and between Fractal paced, Isochronus Paced and Self paced conditions(PRE (before intervention), POST (immediately after the intervention) and POST 60 (60 minutes after the intervention))

研究者

发起方
Egas Moniz - Cooperativa de Ensino Superior, CRL
申办方类型
Other
责任方
Sponsor

研究点 (1)

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