Positive reinforcement targeting abstinence in substance misuse

Not Applicable

• Conditions: Mental Health Research Network; Addictions; Mental and Behavioural Disorders; Mental and behavioural disorders due to use of opioids

• Registration Number: ISRCTN01591254
• Lead Sponsor: South London & Maudsley NHS Foundation Trust and Kings College London (UK)

Brief Summary

2018 Protocol article in https://www.ncbi.nlm.nih.gov/pubmed/29908336 protocol

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-11-19
• Study Completion: 2014-04-30
• Last Update Posted: 21 July 2021

Recruitment & Eligibility

• Sex: All
• Target Recruitment: 552

Inclusion Criteria

1. Aged >18 years
2. Seeking new episode of OST treatment
3. Agree to 12 week treatment programme promoting abstinence
4. Regular users of street heroin in preceding month (self report 15/30 use and all UDS in past 4 weeks opiate positive)
5. Opiate dependent (meeting ICD-10 criteria) and at liberty to participate in the study for 24 weeks
6. Willing and able to provide informed consent
7. Male or female

Exclusion Criteria

1. Pregnant or breastfeeding
2. Active mental health problem
3. Patients referred into treatment under a criminal justice order
4. Patients who cannot read English AND require the service of an interpreter to understand a brief oral description of the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mean number of opiate negative urine test results during weeks 9-12

Secondary Outcome Measures

Name	Time	Method
<br> 1. Retention in treatment at the 3-month and 6-month follow-up<br> 2. Urine test results at the 6-month follow-up (3 months post-CM)<br> 3. Indices of physical, psychological and social well-being<br> 4. Health economic and criminal justice outcomes<br>