NCT02804217Unknown不适用
Identification of Genomic Mutation Profile Using Next Generation Sequencing for Non-small-cell Lung Cancer Patients With Activating EGFR Mutations Harboring Acquired Resistance to the First-generation EGFR TKIs.
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- mutation profile
研究概览
简要总结
Patients with advanced non-small-cell lung cancer (NSCLC) harboring sensitive epithelial growth factor receptor (EGFR) mutations invariably develop acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). Identification of actionable genetic mutations can be helpful for guiding the subsequent treatment. This study aimed to analyze the genetic profile of NSCLC harboring acquired resistance to the first-generation EGFR TKIs using next generation sequencing (NGS).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Histologically proven stage IIIB or IV non-small cell lung cancer
- •patients harboring sensitive EGFR mutations and received first-generation EGFR-TKIs who developed acquired drug resistance
- •patients who can provide pre-treatment (EGFR TKIs) tumor tissues
- •patients with tumor lesions to be re-biopsy after drug resistance
- •patients must sign an informed consent indicating that they are aware of the .investigational nature of the study in keeping with the policy of the hospital.
排除标准
- •History of another malignancy except cured basal cell carcinoma of skin and cured carcinoma in-situ of uterine cervix
- •patients with other systemic diseases
结局指标
主要结局
mutation profile
时间窗: 10 days
次要结局
未报告次要终点
研究者
Yu Xinmin
Director
Zhejiang Cancer Hospital
研究点 (1)
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