Role of Tissue C4d in Differentiation Between Acut e Rejection and HCV Recurrence After Liver Transplantation

Not Applicable

Completed

• Conditions: Liver Disease
• Interventions: Other: liver biopsy

• Registration Number: NCT02209675
• Lead Sponsor: Ain Shams University

Brief Summary

Assessment of the role of tissue C4d complement fragments in liver biopsy as a new marker for differentiating between acute rejection and Hepatitis C (HCV) recurrence in recipients post living donor liver transplantation (LDLT) .As each condition require different treatment

Detailed Description

Role of tissue c4d assessment by immunohistchemistry in liver biopsy in differentiation between recurrent hepatitis c and rejection after liver transplantation.pathological examination may be sometimes confusing between the rejection and recurrent hepatitis C

Study Timeline

• Study Start: 2012-12
• Primary Completion: 2014-06
• Study First Submitted: 2014-07-31
• Study First Submitted QC: 2014-08-05
• Study First Posted: 2014-08-06
• Status Verified: 2014-10
• Study Completion: 2014-10
• Last Update Submitted: 2014-10-12
• Last Update Posted: 2014-10-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Patients transplanted for HCV related disease that are presented with elevated liver enzyme and/or hyperbilirubinemia and normal Abdominal Doppler ultrasound and Magnetic resonance cholangiography (MRCP).

Exclusion Criteria

• Evidence of other causes of elevated liver enzyme and/or hyperbilirubinemia as abnormal Abdominal Doppler ultrasound and/or Magnetic resonance cholangiography MRCP findings.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
patients with elevated liver enzymes	liver biopsy	Patients with elevated liver enzymes and/or hyperbilirubinemia post transplantation for hepatitis C virus related disease will have liver biopsy

Primary Outcome Measures

Name	Time	Method
Number of participants who developed Acute cellular rejection after transplantation	2 years	Assessment of the role of tissue C4d complement fragments in liver biopsy as a new marker for differentiating between acute rejection and hepatitis C recurrence in recipients post living donor liver transplantation (LDLT) .Each condition require different therapeutic management and the differentiation between them by ordinary methods is confusing due to overlapping pathological features between the rejection and recurrent hepatitis C desease

Trial Locations

Locations (1)

Ain Shams center for organ transplant (ASCOT); 🇪🇬 Cairo, Egypt