Exploring the Impact of Supervised Treadmill Aerobic Exercise on Cognitive Function and Apoptotic-Related Biomarkers in Aging Individuals
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 主要终点
- Assessment of body weight as anthropometric measurements
研究概览
简要总结
Positive effects are exerted by participating in moderate exercise training with physical activity which positively affects body health, including cognitive abilities, among older adults. Thus, the investigators are trying to study the potential effects of the supervised aerobic training regimen for 12 weeks on cognitive function among older adults based on molecular changes in cellular apoptosis.
详细描述
Physical activity exerts many positive effects on body health, including cognitive abilities, among older adults. Nevertheless, a paucity of knowledge exists regarding the potential anti-apoptotic benefits of moderate exercise and its potential influence on cognitive function. The objective of the present study was to explore the possible connection between the anti-apoptotic mechanisms associated with exercise and cognitive performance in a cohort of 60 older adults who participated in a 12-week supervised aerobic training regimen.
A total of 120 healthy home residents and older subjects with an age range of 65 to 95 years were enrolled to participate in this study. Only, 60 subjects who met the inclusion criteria were included in this study.
The participants were categorized into two groups, specifically the control group (consisting of 30 individuals) and the exercise group (also comprising 30 individuals), based on their participation in an exercise program. Assessments of cognitive function, leisure-time physical activity (LTPA), and apoptotic-related markers such as Bcl-2, p53, and Cytochrome c were conducted both before and after a 12-week aerobic exercise intervention.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 95 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •home resident older
- •healthy individuals
- •the participants were aged between 65 and 95
排除标准
- •Participants with Any physical impairments or conditions such as endocrine, immune, or psychiatric disorders
- •participants with eating disorders
- •participants' use of any glucocorticoid medications, which might impact the assessment of apoptotic and cognitive functions.
结局指标
主要结局
Assessment of body weight as anthropometric measurements
时间窗: 3 month
the impact of exercise training program on body weight was identified pre and post exercise period. Weight measurements in kilograms from all participants were estimated by employing a standardized approach, utilizing a tape measure and a calibrated Salter Electronic Scale (Digital Pearson Scale; ADAM Equipment Inc., Columbia, MD, USA). The calculated weights were used to estimate BMI of each recpective participant.
Assessment of body height as anthropometric measurements
时间窗: 3 month
the impact of exercise training program on body height was identified pre and post exercise period. A standardized approach, utilizing a tape measure and a calibrated Salter Electronic Scale (Digital Pearson Scale; ADAM Equipment Inc., Columbia, MD, USA) were used to estimate body height of each participants. The values of body height in meters were used in combination with body weight to perform BMI of its respective participant.
Assessment of BMI as as anthropometric measurements
时间窗: 3 month
Assessment of body mass index ( BMI in kg/m\^2)as anthropometric measurements In this test, BMI from body weight and height measurements for each participant were estimated before and after exercise training interventions by using a bioelectrical impedance analysis (BIA) based body composition analyzer (TBF 105, Tanita Corporation, Tokyo, Japan)
次要结局
- Assessment of cognitive abilities(3 month)
- Assessment of serum Bcl-2 as apoptotic-related protein(3 month)
- Assessment of serum cytochrome c as apoptotic-related protein(3 month)
- Assessment of serum p53 (pg/ml) as apoptotic-related protein(3 month)
研究者
Sami Gabr
Clinical investigator
King Saud University