NL-OMON44134已完成不适用
Shifting pain modulation towards anti-nociceptivity: Mechanism-specific pharmacological prevention of post sternotomy pain - MASTER study
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 75
研究概览
简要总结
Trial ended prematurely
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Patients of either sex with American Society of Anesthesiologists score 1, 2 or 3, aged 18 to 75 years planned to undergo elective surgery involving a sternotomy may be enrolled in the study.
排除标准
- •1. Pain scores > 3 (on a 11-point numerical rating scale, NRS) reported for most of the day during the past month (including angina);
- •2. The presence of any chronic pain disorder;
- •3. Regular use of analgesics for any purpose, including SNRIs, gabapentinoids, COX inhibitors or NSAIDs during the previous month;
- •4. Use of MAO-inhibitors within the last 14 days;
- •5. The presence of narrow-angle glaucoma;
- •6. Inability to perform psychophysical testing (eg. in case of cognitive or psychiatric disorders);
- •7. Patients suffering from cognitive dysfunction;
- •8. Patients being treated for depression, or any other mood disorder;
- •9. Inability to give informed consent;
- •10. Inability to communicate with the investigators;
- •11. Known allergies to the study medication:
- •12. Uncontrolled hypertension (diastolic blood pressure > 100 mmHg).
研究者
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