Acute Effects of Nutrition Supplementation on Treatment Efficiency and Hemodynamics During Dialysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Changes in beat-to-beat systolic blood pressure
研究概览
简要总结
The purpose of this study is to examine the effect of nutritional supplementation during hemodialysis treatment on beat-to-beat hemodynamics and treatment efficiency in a crossover design.
详细描述
The consumption of food or nutritional supplements during hemodialysis treatment has been shown to improve nutritional status, improve quality of life, and reduce mortality.
Despite these observations, allowing patients to eat food during hemodialysis treatment is sometimes restricted in the United States. The reasons for this restrictive policy are multi-factorial, but include concerns related to drops in blood pressure BP or a reduced efficiency of solute removal following eating during HD treatment. An alternative to eating solid food is to provide patients with liquid nutritional supplements. Clinics in the US are more likely to allow the consumption of liquid nutritional supplements, however, little is known about the effect that liquid supplements have on blood pressure or treatment efficiency. Therefore, the investigators plan to examine the effect of nutritional supplementation during hemodialysis treatment on hemodynamics and treatment efficiency in a crossover design.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Receiving hemodialysis treatment three times per week, on hemodialysis for greater than three months, receive medical clearance from a Nephrologists
排除标准
- •Milk or soy allergy, more than 4 hypotensive events requiring intervention in the last two weeks, hospitalized due to hypotension in the previous week
研究组 & 干预措施
Standard Hemodialysis
Participants will be monitored during their normal hemodialysis treatment with no intervention administered
Hemodialysis with Nutrition Supplement
Participants will be monitored during a normal hemodialysis treatment in which they consume 1-8oz can of Nepro.
干预措施: Nepro (Dietary Supplement)
Nutrition Supplement
Participants will be monitored while drinking 1-8oz can of Nepro with no hemodialysis treatment.
干预措施: Nepro (Dietary Supplement)
结局指标
主要结局
Changes in beat-to-beat systolic blood pressure
时间窗: Duration of each treatment (approximately four hours), treatments will be one week apart for a total of three weeks
Beat-to-beat blood pressure will be monitored throughout the treatment by finger plethysmography
次要结局
- Gastrointestinal symptoms during treatment by a rating scale(Duration of each treatment (approximately four hours), treatments will be one week apart for a total of three weeks)
- Treatment efficiency measured by urea removal(Duration of each treatment (approximately four hours), treatments will be one week apart for a total of three weeks)