epidermise sheet cultured from autologous revertant somatic mosaic site (epidermise sheet cultured from autologous revertant somatic mosaic site)
- Conditions
- epidermolytic ichthyosis
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 3
Patients who are diagnosed with epidermolytic ichthyosis and have a revertant somatic mutation, the responsible gene mutation * was identified by genetic testing.
- Heterozygote mutation must be demonstrated in either keratin 1 (KRT1) or keratin 10 (KRT10).
Patients hypersensitive to penicillin, kanamycin, streptomycin, and amphotericin B antibiotics. Patients with a history of hypersensitivity to penicillin antibiotics and aminoglycoside antibiotics. Patients who are allergic to cattle, mice and pigs. Patients with malignant neoplastic lesions other than the skin, or patients with a history within 3 years prior to enrollment.
Study & Design
- Study Type
- Interventional
- Study Design
- single assignment
- Primary Outcome Measures
Name Time Method - Improvement rate of hyperkeratosis 4 weeks after the final transplant (%)
- Secondary Outcome Measures
Name Time Method Average improvement rate of hyperkeratosis up to 24 weeks after initial transplantation up to 24 weeks after initial transplantation Average improvement rate of hyperkeratosis up to 24 weeks after initial transplantation (%)
Average improvement rate of site-specific hyperkeratosis up to 24 weeks after initial transplantation up to 24 weeks after initial transplantation Average improvement rate of site-specific hyperkeratosis up to 24 weeks after initial transplantation (%)
Improvement rate of site-specific hyperkeratosis 4 weeks after final transplantation 4 weeks after final transplantation Improvement rate of site-specific hyperkeratosis 4 weeks after final transplantation (%)